Publication detail

In Vitro Characterization of Poly(Lactic Acid)/Poly(Hydroxybutyrate)/Thermoplastic Starch Blends for Tissue Engineering Application

ALEXY, P. MONCMANOVÁ, B. PLAVEC, R. TOMANOVÁ, K. MENČÍK, P. ŽIARAN, S.

Original Title

In Vitro Characterization of Poly(Lactic Acid)/Poly(Hydroxybutyrate)/Thermoplastic Starch Blends for Tissue Engineering Application

Type

journal article in Web of Science

Language

English

Original Abstract

Complex in vitro characterization of a blended material based on Poly(Lactic Acid), Poly(Hydroxybutyrate), and Thermoplastic Starch (PLA/PHB/TPS) was performed in order to evaluate its potential for application in the field of tissue engineering. We focused on the biological behavior of the material as well as its mechanical and morphological properties. We also focused on the potential of the blend to be processed by the 3D printer which would allow the fabrication of the custom-made scaffold. Several blends recipes were prepared and characterized. This material was then studied in the context of scaffold fabrication. Scaffold porosity, wettability, and cell-scaffold interaction were evaluated as well. MTT test and the direct contact cytotoxicity test were applied in order to evaluate the toxic potential of the blended material. Biocompatibility studies were performed on the human chondrocytes. According to our results, we assume that material had no toxic effect on the cell culture and therefore could be considered as biocompatible. Moreover, PLA/PHB/TPS blend is applicable for 3D printing. Printed scaffolds had highly porous morphology and were able to absorb water as well. In addition, cells could adhere and proliferate on the scaffold surface. We conclude that this blend has potential for scaffold engineering.

Keywords

PLA; PHB; TPS blend; 3D printing; viscosimetry; porosity; biocompatibility; tissue engineering

Authors

ALEXY, P.; MONCMANOVÁ, B.; PLAVEC, R.; TOMANOVÁ, K.; MENČÍK, P.; ŽIARAN, S.

Released

27. 5. 2021

Publisher

SAGE PUBLICATIONS INC

Location

THOUSAND OAKS

ISBN

0963-6897

Periodical

CELL TRANSPLANTATION

Year of study

30

Number

1

State

United States of America

Pages from

1

Pages to

12

Pages count

12

URL

https://www.webofscience.com/wos/woscc/full-record/WOS:000693646800001

BibTex

@article{BUT177259,
  author="Pavol {Alexy} and Barbora {Moncmanová} and Roderik {Plavec} and Katarína {Tomanová} and Přemysl {Menčík} and Stanislav {Žiaran}",
  title="In Vitro Characterization of Poly(Lactic Acid)/Poly(Hydroxybutyrate)/Thermoplastic Starch Blends for Tissue Engineering Application",
  journal="CELL TRANSPLANTATION",
  year="2021",
  volume="30",
  number="1",
  pages="1--12",
  doi="10.1177/09636897211021003",
  issn="0963-6897",
  url="https://www.webofscience.com/wos/woscc/full-record/WOS:000693646800001"
}