Publication detail

Ratiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

JANASIK, D. JASINSKI, K. WEGLARZ, W. NEMEC, I. JEWULA, P. KRAWCZYK, T.

Original Title

Ratiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches

Type

journal article in Web of Science

Language

English

Original Abstract

Hydrazone-based molecular switches serve as eflicient ratiometric pH-sensitive agents that can be tracked with F-19 NMR/MRI and H-1 NMR. Structural changes induced between pH 3 and 4 lead to signal appearance and disappearance at H-1 and F-19 NMR spectra allowing ratiometric pH measurements. The most pronounced are resonances of the CF3 group shifted by 1.8 ppm with F-19 NMR and a hydrazone proton shifted by 2 ppm with H-1 NMR.

Keywords

Magnetic resonance imaging, Fluorine, pH, Molecular structure, Nuclear magnetic resonance spectroscopy

Authors

JANASIK, D.; JASINSKI, K.; WEGLARZ, W.; NEMEC, I.; JEWULA, P.; KRAWCZYK, T.

Released

14. 3. 2022

Publisher

American Chemical Society

Location

WASHINGTON

ISBN

1520-6882

Periodical

Analytical Chemistry

Year of study

94

Number

8

State

United States of America

Pages from

3427

Pages to

3431

Pages count

5

URL

https://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04978

Full text in the Digital Library

http://hdl.handle.net/11012/204475

BibTex

@article{BUT177356,
  author="Dawid {Janasik} and Krzysztof {Jasinski} and Wladyslav P. {Weglarz} and Ivan {Nemec} and Pawel {Jewula} and Tomasz {Krawczyk}",
  title="Ratiometric pH-Responsive F-19 Magnetic Resonance Imaging Contrast Agents Based on Hydrazone Switches",
  journal="Analytical Chemistry",
  year="2022",
  volume="94",
  number="8",
  pages="3427--3431",
  doi="10.1021/acs.analchem.1c04978",
  issn="1520-6882",
  url="https://pubs.acs.org/doi/abs/10.1021/acs.analchem.1c04978"
}