Publication detail

Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M-Type Voltage-Gated Potassium Channels

ABUDLLAEVA, O. SAHALIANOV, I. EJNEBY, M. JAKEŠOVÁ, M. ZOZOULENKO, I. LIIN, S. GLOWACKI, E.

Original Title

Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M-Type Voltage-Gated Potassium Channels

Type

journal article in Web of Science

Language

English

Original Abstract

H2O2 plays a significant role in a range of physiological processes where it performs vital tasks in redox signaling. The sensitivity of many biological pathways to H2O2 opens up a unique direction in the development of bioelectronics devices to control levels of reactive-oxygen species (ROS). Here a microfabricated ROS modulation device that relies on controlled faradaic reactions is presented. A concentric pixel arrangement of a peroxide-evolving cathode surrounded by an anode ring which decomposes the peroxide, resulting in localized peroxide delivery is reported. The conducting polymer (poly(3,4-ethylenedioxythiophene) (PEDOT), is exploited as the cathode. PEDOT selectively catalyzes the oxygen reduction reaction resulting in the production of hydrogen peroxide (H2O2). Using electrochemical and optical assays, combined with modeling, the performance of the devices is benchmarked. The concentric pixels generate tunable gradients of peroxide and oxygen concentrations. The faradaic devices are prototyped by modulating human H2O2-sensitive Kv7.2/7.3 (M-type) channels expressed in a single-cell model (Xenopus laevis oocytes). The Kv7 ion channel family is responsible for regulating neuronal excitability in the heart, brain, and smooth muscles, making it an ideal platform for faradaic ROS stimulation. The results demonstrate the potential of PEDOT to act as an H2O2 delivery system, paving the way to ROS-based organic bioelectronics.

Keywords

electrochemistry; organic bioelectronics; potassium channels; reactive oxygen species; Xenopus laevis oocytes

Authors

ABUDLLAEVA, O.; SAHALIANOV, I.; EJNEBY, M.; JAKEŠOVÁ, M.; ZOZOULENKO, I.; LIIN, S.; GLOWACKI, E.

Released

1. 1. 2022

Publisher

Wiley

Location

HOBOKEN

ISBN

2198-3844

Periodical

Advanced Science

Year of study

9

Number

3

State

United States of America

Pages from

1

Pages to

14

Pages count

14

URL

https://onlinelibrary.wiley.com/doi/10.1002/advs.202103132

Full text in the Digital Library

http://hdl.handle.net/11012/204600

BibTex

@article{BUT177521,
  author="Oliya S. {Abudllaeva} and Ihor {Sahalianov} and Malin Silverå {Ejneby} and Marie {Jakešová} and Igor {Zozoulenko} and Sara I. {Liin} and Eric Daniel {Glowacki}",
  title="Faradaic Pixels for Precise Hydrogen Peroxide Delivery to Control M-Type Voltage-Gated Potassium Channels",
  journal="Advanced Science",
  year="2022",
  volume="9",
  number="3",
  pages="1--14",
  doi="10.1002/advs.202103132",
  issn="2198-3844",
  url="https://onlinelibrary.wiley.com/doi/10.1002/advs.202103132"
}