Publication detail

Automatic 3D analysis of the ex-vivo porcine lumbar interbody fusion based on X-ray micro computed tomography data

LÁZŇOVSKÝ, J. BŘÍNEK, A. ZIKMUND, T. BOUDOVÁ, M. VOJTOVÁ, L. DORAZILOVÁ, J. TRUNEC, M. ŠŤASTNÝ, P. KRTIČKA, M. PLÁNKA, L. IRA, D. FALDYNA, M. KAISER, J.

Original Title

Automatic 3D analysis of the ex-vivo porcine lumbar interbody fusion based on X-ray micro computed tomography data

Type

journal article in Web of Science

Language

English

Original Abstract

Spinal fusion is a surgical procedure used to join two or more vertebrae to prevent movement between them. This surgical procedure is considered in patients suffering from a wide range of degenerative spinal diseases or vertebral fractures. The success rate of spinal fusion is frequently evaluated subjectively using X-ray computed tomography. The pig was chosen as an animal model for spinal fusion, since its spinal structure is similar to the human spine. Our paper presents an automatic approach for pig’s spinal fusion evaluation in 3D. The proposed approach is based on the determination of the vertebral fused area, which reflects the fusion quality. The approach was applied and tested on microCT (μCT) data of fused porcine vertebrae ex-vivo. In our study, three types of implants were used to perform spinal fusion: the iliac crest bone graft used as the gold standard, and two types of novel scaffold implants based on the polymer/ceramic porous foam involving either growth factors or polyphosphates. The evaluation worked automatically for all three types of used implants, and the fusion quality was determined quantitatively. The calculation is based on the detection of the fused area and area of facies intervertebralis, so the percentual representation of the vertebral joint can be determined. Since this approach is versatile and is described in detail as a guide for image processing the data of vertebrae fusion, this methodology has the potential to establish a standard approach for evaluating the fusion quality in ex-vivo samples that can be tested on clinical data.

Keywords

Vertebrae fusion; Spinal fusion; Computed tomography; Image processing; Regenerative medicine; Lumbar spinal surgery

Authors

LÁZŇOVSKÝ, J.; BŘÍNEK, A.; ZIKMUND, T.; BOUDOVÁ, M.; VOJTOVÁ, L.; DORAZILOVÁ, J.; TRUNEC, M.; ŠŤASTNÝ, P.; KRTIČKA, M.; PLÁNKA, L.; IRA, D.; FALDYNA, M.; KAISER, J.

Released

22. 3. 2022

Publisher

Elsevier Ltd

Location

Netherlands

ISBN

0010-4825

Periodical

COMPUTERS IN BIOLOGY AND MEDICINE

Year of study

145

Number

105438

State

United States of America

Pages from

1

Pages to

12

Pages count

12

URL

https://www.sciencedirect.com/science/article/pii/S001048252200230X

BibTex

@article{BUT178300,
  author="Jakub {Lázňovský} and Adam {Břínek} and Tomáš {Zikmund} and Markéta {Boudová} and Lucy {Vojtová} and Jana {Matulová} and Martin {Trunec} and Přemysl {Šťastný} and Milan {Krtička} and Ladislav {Plánka} and Daniel {Ira} and Martin {Faldyna} and Jozef {Kaiser}",
  title="Automatic 3D analysis of the ex-vivo porcine lumbar interbody fusion based on X-ray micro computed tomography data",
  journal="COMPUTERS IN BIOLOGY AND MEDICINE",
  year="2022",
  volume="145",
  number="105438",
  pages="1--12",
  doi="10.1016/j.compbiomed.2022.105438",
  issn="0010-4825",
  url="https://www.sciencedirect.com/science/article/pii/S001048252200230X"
}