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TOROPITSYN, E. PRAVDA, M. REBENDA, D. ŠČIGALKOVÁ, I. VRBKA, M. VELEBNÝ, V.
Original Title
A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase
Type
journal article in Web of Science
Language
English
Original Abstract
Osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. OA is often associated with the loss of viscoelastic and tribological properties of synovial fluid (SF) due to degradation of hyaluronic acid (HA) by reactive oxygen species (ROS) and hyaluronidases. Viscosupplementation is one of the ways how to effectively restore SF functions. However, current viscosupplementation products provide only temporal therapeutic effect because of short biological half-life. In this article we describe a novel device for viscosupplementation (NV) based on the cross-linked tyramine derivative of HA, chondroitin sulfate (CS), and high molecular weight HA by online determination of viscoelastic properties loss during degradation by ROS and hyaluronidase. Rheological and tribological properties of developed viscosupplement were compared with HA solutions with different molecular weights in the range 500–2000 kDa, which are currently commonly used as medical devices for viscosupplementation treatment. Moreover, based on clinical practice and scientific literature all samples were also diluted by model OA SF in the ratio 1:1 (vol/vol) to better predict final properties after injection to the joint. The observed results confirmed that NV exhibits appropriate rheological properties (viscosity, elastic, and viscous moduli) comparable with healthy SF and maintain them during degradation for a significantly longer time than HA solutions with molecular weight in the range 500–2000 kDa and cross-linked material without CS.
Keywords
hyaluronidase, ROS, tyramine derivative of hyaluronic acid, viscoelastic properties,viscosupplementation
Authors
TOROPITSYN, E.; PRAVDA, M.; REBENDA, D.; ŠČIGALKOVÁ, I.; VRBKA, M.; VELEBNÝ, V.
Released
21. 6. 2022
Publisher
John Wiley & Sons Inc.
Location
Hoboken, New Jersey, USA
ISBN
1552-4981
Periodical
Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)
Year of study
110
Number
2
State
United States of America
Pages from
2595
Pages to
2611
Pages count
17
URL
https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114
BibTex
@article{BUT178319, author="Evgeniy {Toropitsyn} and Martin {Pravda} and David {Rebenda} and Ivana {Ščigalková} and Martin {Vrbka} and Vladimír {Velebný}", title="A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase", journal="Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)", year="2022", volume="110", number="2", pages="2595--2611", doi="10.1002/jbm.b.35114", issn="1552-4981", url="https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114" }