Publication detail

Heart rate and age modulate retinal pulsatile patterns

LABOUNKOVÁ, I. LABOUNEK, R. KOLÁŘ, R. TORNOW, R. BABBS, C. MCCLELLAND, C. MILLER, B. NESTRAŠIL, I.

Original Title

Heart rate and age modulate retinal pulsatile patterns

Type

journal article in Web of Science

Language

English

Original Abstract

Video-recordings of retinal pulsatile patterns in human eye are modulated by heart rate and age. This invivo evidence fundamentally impacts modeling of retinal function and clinical design in wide range of medical specialties. Theoretical models of retinal hemodynamics showed the modulation of retinal pulsatile patterns (RPPs) by heart rate (HR), yet in-vivo validation and scientific merit of this biological process is lacking. Such evidence is critical for result interpretation, study design, and (patho-)physiological modeling of human biology spanning applications in various medical specialties. In retinal hemodynamic video-recordings, we characterize the morphology of RPPs and assess the impact of modulation by HR or other variables. Principal component analysis isolated two RPPs, i.e., spontaneous venous pulsation (SVP) and optic cup pulsation (OCP). Heart rate modulated SVP and OCP morphology (p(FDR) < 0.05); age modulated SVP morphology (p(FDR) < 0.05). In addition, age and HR demonstrated the effect on between-group differences. This knowledge greatly affects future study designs, analyses of between-group differences in RPPs, and biophysical models investigating relationships between RPPs, intracranial, intraocular pressures, and cardiovascular physiology.

Keywords

blood flow; image processing; ocular hypertension; optical imaging; translational research

Authors

LABOUNKOVÁ, I.; LABOUNEK, R.; KOLÁŘ, R.; TORNOW, R.; BABBS, C.; MCCLELLAND, C.; MILLER, B.; NESTRAŠIL, I.

Released

14. 6. 2022

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

2399-3642

Periodical

Communications Biology

Year of study

5

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

10

Pages count

10

URL

https://www.nature.com/articles/s42003-022-03441-6

Full text in the Digital Library

http://hdl.handle.net/11012/208117

BibTex

@article{BUT178352,
  author="Ivana {Labounková} and René {Labounek} and Radim {Kolář} and Ralf-Peter {Tornow} and Charles F. {Babbs} and Collin {McClelland} and Benjamin R. {Miller} and Igor {Nestrašil}",
  title="Heart rate and age modulate retinal pulsatile patterns",
  journal="Communications Biology",
  year="2022",
  volume="5",
  number="1",
  pages="1--10",
  doi="10.1038/s42003-022-03441-6",
  issn="2399-3642",
  url="https://www.nature.com/articles/s42003-022-03441-6"
}