Publication detail

Serotonin limits generation of chromaffin cells during adrenal organ development

KAMENEVA P. MELNIKOVA V. KASTRITI M.E. KURTOVA A. KRYUKOV E. MURTAZINA A. FAURE L. POVERENNAYA I. ARTEMOV A. KALININA T. KUDRYASHOV N. BADER M. SKODA J. CHLAPEK P. CURYLOVA L. SOURADA L. NERADIL J. TESAŘOVÁ M. GASPAR P. YAKUSHOV V.D. SHEFTEL B.I. ZIKMUND T. KAISER J. FRIED K. ALENINA N. VORONEZSHKAYA E. and ADAMEYKO I

Original Title

Serotonin limits generation of chromaffin cells during adrenal organ development

Type

journal article in Web of Science

Language

English

Original Abstract

Adrenal glands are major organs regulating stress response., Melnikova et al., show that local release of serotonin limits adrenalin-producing cell number during rodent development, a mechanism which has implications for neuroblastoma development and stress-related maternal effects transmitted to progeny. Adrenal glands are the major organs releasing catecholamines and regulating our stress response. The mechanisms balancing generation of adrenergic chromaffin cells and protecting against neuroblastoma tumors are still enigmatic. Here we revealed that serotonin (5HT) controls the numbers of chromaffin cells by acting upon their immediate progenitor "bridge" cells via 5-hydroxytryptamine receptor 3A (HTR3A), and the aggressive HTR3A(high) human neuroblastoma cell lines reduce proliferation in response to HTR3A-specific agonists. In embryos (in vivo), the physiological increase of 5HT caused a prolongation of the cell cycle in "bridge" progenitors leading to a smaller chromaffin population and changing the balance of hormones and behavioral patterns in adulthood. These behavioral effects and smaller adrenals were mirrored in the progeny of pregnant female mice subjected to experimental stress, suggesting a maternal-fetal link that controls developmental adaptations. Finally, these results corresponded to a size-distribution of adrenals found in wild rodents with different coping strategies.

Keywords

adrenal organ; serotonin; development; biology

Authors

KAMENEVA P.; MELNIKOVA V.; KASTRITI M.E.; KURTOVA A.; KRYUKOV E.; MURTAZINA A.; FAURE L.; POVERENNAYA I.; ARTEMOV A.; KALININA T.; KUDRYASHOV N.; BADER M.; SKODA J.; CHLAPEK P.; CURYLOVA L.; SOURADA L. NERADIL J.; TESAŘOVÁ M.; GASPAR P.; YAKUSHOV V.D.; SHEFTEL B.I.; ZIKMUND T.; KAISER J.; FRIED K. ALENINA N.; VORONEZSHKAYA E. and ADAMEYKO I

Released

25. 5. 2022

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

2041-1723

Periodical

NATURE COMMUNICATIONS

Year of study

13

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

21

Pages count

21

URL

https://www.nature.com/articles/s41467-022-30438-w

BibTex

@article{BUT178468,
  author="KAMENEVA P. and MELNIKOVA V. and KASTRITI M.E. and KURTOVA A. and KRYUKOV E. and MURTAZINA A. and FAURE L. and POVERENNAYA I. and ARTEMOV A. and KALININA T. and KUDRYASHOV N. and BADER M. and SKODA J. and CHLAPEK P. and CURYLOVA L. and SOURADA L. NERADIL J. and TESAŘOVÁ M. and GASPAR P. and YAKUSHOV V.D. and SHEFTEL B.I. and ZIKMUND T. and KAISER J. and FRIED K. ALENINA N. and VORONEZSHKAYA E. and ADAMEYKO I",
  title="Serotonin limits generation of chromaffin cells during adrenal organ development",
  journal="NATURE COMMUNICATIONS",
  year="2022",
  volume="13",
  number="1",
  pages="1--21",
  doi="10.1038/s41467-022-30438-w",
  issn="2041-1723",
  url="https://www.nature.com/articles/s41467-022-30438-w"
}