Publication detail

Light-Propelled Nanorobots for Facial Titanium Implants Biofilms Removal

USSIA, M. URSO, M. KMENT, Š. FIALOVÁ, T. KLÍMA, K. DOLEŽELÍKOVÁ, K. PUMERA, M.

Original Title

Light-Propelled Nanorobots for Facial Titanium Implants Biofilms Removal

Type

journal article in Web of Science

Language

English

Original Abstract

Titanium miniplates are biocompatible materials used in modern oral and maxillofacial surgery to treat facial bone fractures. However, plate removal is often required due to implant complications. Among them, a biofilm formation on an infected miniplate is associated with severe inflammation, which frequently results in implant failure. In light of this, new strategies to control or treat oral bacterial biofilm are of high interest. Herein, the authors exploit the ability of nanorobots against multispecies bacterial biofilm grown onto facial commercial titanium miniplate implants to simulate pathogenic conditions of the oral microenvironment. The strategy is based on the use of light-driven self-propelled tubular black-TiO2/Ag nanorobots, that unlike traditional ones, exhibit an extended absorption and motion actuation from UV to the visible-light range. The motion analysis is performed separately over UV, blue, and green light irradiation and shows different motion behaviors, including a fast rotational motion that decreases with increasing wavelengths. The biomass reduction is monitored by evaluating LIVE/DEAD fluorescent and digital microscope images of bacterial biofilm treated with the nanorobots under motion/no-motion conditions. The current study and the obtained results can bring significant improvements for effective therapy of infected metallic miniplates by biofilm.

Keywords

bacteria; black TiO; (2); dental implants; nanomotors; silver; UV light; visible light

Authors

USSIA, M.; URSO, M.; KMENT, Š.; FIALOVÁ, T.; KLÍMA, K.; DOLEŽELÍKOVÁ, K.; PUMERA, M.

Released

1. 6. 2022

Publisher

Wiley VCH

Location

WEINHEIM

ISBN

1613-6829

Periodical

Small

Year of study

18

Number

22

State

Federal Republic of Germany

Pages from

1

Pages to

10

Pages count

10

URL

https://onlinelibrary.wiley.com/doi/10.1002/smll.202200708

Full text in the Digital Library

http://hdl.handle.net/11012/208469

BibTex

@article{BUT178690,
  author="Martina {Ussia} and Mario {Urso} and Štěpán {Kment} and Tatiana {Fialová} and Karel {Klíma} and Kristýna {Číhalová} and Martin {Pumera}",
  title="Light-Propelled Nanorobots for Facial Titanium Implants Biofilms Removal",
  journal="Small",
  year="2022",
  volume="18",
  number="22",
  pages="1--10",
  doi="10.1002/smll.202200708",
  issn="1613-6829",
  url="https://onlinelibrary.wiley.com/doi/10.1002/smll.202200708"
}