Publication detail

Enzyme-Photocatalyst Tandem Microrobot Powered by Urea for Escherichia coli Biofilm Eradication

VILLA, K. SOPHA, H. ZELENKA, J. MOTOLA, M. DĚKANOVSKÝ, L. CHYLII BEKETOVA, D. MACÁK, J. RUML, T. PUMERA, M.

Original Title

Enzyme-Photocatalyst Tandem Microrobot Powered by Urea for Escherichia coli Biofilm Eradication

Type

journal article in Web of Science

Language

English

Original Abstract

Urinary-based infections affect millions of people worldwide. Such bacterial infections are mainly caused by Escherichia coli (E. coli) biofilm formation in the bladder and/or urinary catheters. Herein, the authors present a hybrid enzyme/photocatalytic microrobot, based on urease-immobilized TiO2/CdS nanotube bundles, that can swim in urea as a biocompatible fuel and respond to visible light. Upon illumination for 2 h, these microrobots are able to remove almost 90% of bacterial biofilm, due to the generation of reactive radicals, while bare TiO2/CdS photocatalysts (non-motile) or urease-coated microrobots in the dark do not show any toxic effect. These results indicate a synergistic effect between the self-propulsion provided by the enzyme and the photocatalytic activity induced under light stimuli. This work provides a photo-biocatalytic approach for the design of efficient light-driven microrobots with promising applications in microbiology and biomedicine.

Keywords

bacterial biofilms; enzymatic; micromotors; photocatalysis; TiO; (2) nanotubes; urinary infections

Authors

VILLA, K.; SOPHA, H.; ZELENKA, J.; MOTOLA, M.; DĚKANOVSKÝ, L.; CHYLII BEKETOVA, D.; MACÁK, J.; RUML, T.; PUMERA, M.

Released

1. 9. 2022

Publisher

Wiley-VCH

Location

WEINHEIM

ISBN

1613-6829

Periodical

Small

Year of study

18

Number

36

State

Federal Republic of Germany

Pages from

1

Pages to

8

Pages count

8

URL

https://onlinelibrary.wiley.com/doi/10.1002/smll.202106612

BibTex

@article{BUT178709,
  author="Katherine {Villa} and Hanna Ingrid {Sopha} and Jaroslav {Zelenka} and Martin {Motola} and Lukáš {Děkanovský} and Darya {Chylii Beketova} and Jan {Macák} and Tomáš {Ruml} and Martin {Pumera}",
  title="Enzyme-Photocatalyst Tandem Microrobot Powered by Urea for Escherichia coli Biofilm Eradication",
  journal="Small",
  year="2022",
  volume="18",
  number="36",
  pages="1--8",
  doi="10.1002/smll.202106612",
  issn="1613-6829",
  url="https://onlinelibrary.wiley.com/doi/10.1002/smll.202106612"
}