Publication detail

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

OPATŘIL, L. PANOVSKÝ, R. LUZ MOJICA-PISCIOTTI, M. MÁCHAL, J. KREJČÍ, J. HOLEČEK, T. MASÁROVÁ, L. FEITOVÁ, V. GODAVA, J. KINCL, V. KEPÁK, T. ZÁVODNÁ, G. ŠPINAROVÁ, L.

Original Title

Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant

Type

journal article in Web of Science

Language

English

Original Abstract

Rest pulmonary circulation parameters such as pulmonary transit time (PTT), heart rate corrected PTT (PTTc) and pulmonary transit beats (PTB) can be evaluated using several methods, including the first-pass perfusion from cardiovascular magnetic resonance. As previously published, up to 58% of patients after HTx have diastolic dysfunction detectable only in stress conditions. By using adenosine stress perfusion images, stress analogues of the mentioned parameters can be assessed. By dividing stress to rest biomarkers, potential new ratio parameters (PTT ratio and PTTc ratio) can be obtained. The objectives were to (1) provide more evidence about stress pulmonary circulation biomarkers, (2) present stress to rest ratio parameters, and (3) assess these biomarkers in patients with presumed diastolic dysfunction after heart transplant (HTx) and in childhood cancer survivors (CCS) without any signs of diastolic dysfunction. In this retrospective study, 48 patients after HTx, divided into subgroups based on echocardiographic signs of diastolic dysfunction (41 without, 7 with) and 39 CCS were enrolled. PTT was defined as the difference between the onset time of the signal intensity increase in the left and the right ventricle. PTT in rest conditions were without significant differences when comparing the CCS and HTx subgroup without diastolic dysfunction (4.96 +/- 0.93 s vs. 5.51 +/- 1.14 s, p = 0.063) or with diastolic dysfunction (4.96 +/- 0.93 s vs. 6.04 +/- 1.13 s, p = 0.13). However, in stress conditions, both PTT and PTTc were significantly lower in the CCS group than in the HTx subgroups, (PTT: 3.76 +/- 0.78 s vs. 4.82 +/- 1.03 s, p < 0.001; 5.52 +/- 1.56 s, p = 0.002). PTT ratio and PTTc ratio were below 1 in all groups. In conclusion, stress pulmonary circulation parameters obtained from CMR showed prolonged PTT and PTTc in HTx groups compared to CCS, which corresponds with the presumption of underlying diastolic dysfunction. The ratio parameters were less than 1.

Keywords

TRANSIT-TIME; ADENOSINE; FAILURE; RECEPTORS

Authors

OPATŘIL, L.; PANOVSKÝ, R.; LUZ MOJICA-PISCIOTTI, M.; MÁCHAL, J.; KREJČÍ, J.; HOLEČEK, T.; MASÁROVÁ, L.; FEITOVÁ, V.; GODAVA, J.; KINCL, V.; KEPÁK, T.; ZÁVODNÁ, G.; ŠPINAROVÁ, L.

Released

12. 4. 2022

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

2045-2322

Periodical

Scientific Reports

Year of study

12

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

10

Pages count

10

URL

https://nature.com/articles/s41598-022-09739-z

BibTex

@article{BUT178954,
  author="Lukáš {Opatřil} and Roman {Panovský} and Mary {Luz Mojica-Pisciotti} and Jan {Máchal} and Jan {Krejčí} and Tomáš {Holeček} and Lucia {Masárová} and Věra {Feitová} and Július {Godava} and Vladimír {Kincl} and Tomáš {Kepák} and Gabriela {Závodná} and Lenka {Špinarová}",
  title="Stress pulmonary circulation parameters assessed by a cardiovascular magnetic resonance in patients after a heart transplant",
  journal="Scientific Reports",
  year="2022",
  volume="12",
  number="1",
  pages="1--10",
  doi="10.1038/s41598-022-09739-z",
  issn="2045-2322",
  url="https://nature.com/articles/s41598-022-09739-z"
}