Publication detail

Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems

TRUDIČOVÁ, M. PAPEŽÍKOVÁ, H. SEDLÁČEK, P. PEKAŘ, M.

Original Title

Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems

Type

conference paper

Language

English

Original Abstract

The transport and barrier properties are important material characteristics in terms of the development of the targeted drug delivery systems. Therefore, this work focused on the study of the possibility of influencing these properties and internal architecture in a model hydrogel system formed by a semi-interpenetrating polymer network with an incorporated polyelectrolyte component. Due to its application potential and its extensive use in medicine, poly(2-hydroxyethyl methacrylate) was chosen as the model hydrogel system for this work. Sodium polystyrene sulfonate was used as the interpenetrating linear polymer. Scanning electron microscopy was used to examine the structure of the three-dimensional hydrogel network. Transport properties were monitored by diffusion tests. Furthermore, diffusion through the hydrogel (barrier properties) was monitored using diffusion cells (Franz cells, horizontal cells). The usability of the semi-interpenetrating polymer network concept for the preparation of materials with tunable relevant properties was confirmed on the proposed materials.

Keywords

hydrogel, poly(2-hydroxyethyl methacrylate), transport properties, drug delivery systems

Authors

TRUDIČOVÁ, M.; PAPEŽÍKOVÁ, H.; SEDLÁČEK, P.; PEKAŘ, M.

Released

1. 1. 2022

Publisher

TANGER Ltd.

Location

Ostrava

ISBN

978-80-88365-00-6

Book

CONFERENCE PROCEEDINGS - NANOCON 2021

Pages from

280

Pages to

285

Pages count

6

URL

https://www.confer.cz/nanocon/2021/4350-tailoring-the-internal-microstructure-of-the-hydrogels-based-on-poly-hema-targeted-for-drug-delivery-systems

Full text in the Digital Library

http://hdl.handle.net/11012/208761

BibTex

@inproceedings{BUT179527,
  author="Monika {Trudičová} and Hana {Papežíková} and Petr {Sedláček} and Miloslav {Pekař}",
  title="Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems",
  booktitle="CONFERENCE PROCEEDINGS - NANOCON 2021",
  year="2022",
  pages="280--285",
  publisher="TANGER Ltd.",
  address="Ostrava",
  doi="10.37904/nanocon.2021.4350",
  isbn="978-80-88365-00-6",
  url="https://www.confer.cz/nanocon/2021/4350-tailoring-the-internal-microstructure-of-the-hydrogels-based-on-poly-hema-targeted-for-drug-delivery-systems"
}