Publication detail

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

MITREVSKA, K. CERNEI, N. MICHÁLKOVÁ, H. MERLOS RODRIGO, M. SIVÁK, L. HEGER, Z. ZÍTKA, O. KOPEL, P. ADAM, V. MILOSAVLJEVIĆ, V.

Original Title

Platinum-based drug-induced depletion of amino acids in the kidneys and liver

Type

journal article in Web of Science

Language

English

Original Abstract

Cisplatin (cis-diamminedichloroplatinum II; CDDP) is a widely used cytostatic agent; however, it tends to promote kidney and liver disease, which are a major signs of drug-induced toxicity. Platinum compounds are often presented as alternative therapeutics and subsequently easily dispersed in the environment as contaminants. Due to the major roles of the liver and kidneys in removing toxic materials from the human body, we performed a comparative study of the amino acid profiles in chicken liver and kidneys before and after the application of CDDP and platinum nanoparticles (PtNPs-10 and PtNPs-40). The treatment of the liver with the selected drugs affected different amino acids; however, Leu and Arg were decreased after all treatments. The treatment of the kidneys with CDDP mostly affected Val; PtNPs-10 decreased Val, Ile and Thr; and PtNPs-40 affected only Pro. In addition, we tested the same drugs on two healthy cell lines, HaCaT and HEK-293, and ultimately explored the amino acid profiles in relation to the tricarboxylic acid cycle (TCA) and methionine cycle, which revealed that in both cell lines, there was a general increase in amino acid concentrations associated with changes in the concentrations of the metabolites of these cycles.

Keywords

amino acids; chicken embryo; platinum nanoparticles; TCA; methionine cycle; toxicity

Authors

MITREVSKA, K.; CERNEI, N.; MICHÁLKOVÁ, H.; MERLOS RODRIGO, M.; SIVÁK, L.; HEGER, Z.; ZÍTKA, O.; KOPEL, P.; ADAM, V.; MILOSAVLJEVIĆ, V.

Released

21. 9. 2022

ISBN

2234-943X

Periodical

Frontiers in Oncology

Year of study

12

Number

986045

State

Swiss Confederation

Pages from

1

Pages to

20

Pages count

20

URL

https://doi.org/10.3389/fonc.2022.986045

BibTex

@article{BUT179946,
  author="MITREVSKA, K. and CERNEI, N. and MICHÁLKOVÁ, H. and MERLOS RODRIGO, M. and SIVÁK, L. and HEGER, Z. and ZÍTKA, O. and KOPEL, P. and ADAM, V. and MILOSAVLJEVIĆ, V.",
  title="Platinum-based drug-induced depletion of amino acids in the kidneys and liver",
  journal="Frontiers in Oncology",
  year="2022",
  volume="12",
  number="986045",
  pages="1--20",
  doi="10.3389/fonc.2022.986045",
  issn="2234-943X",
  url="https://doi.org/10.3389/fonc.2022.986045"
}