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MIŠÍK, O. MALÝ, M. CEJPEK, O. SZABOVÁ, J. LÍZAL, F.
Original Title
Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer
Type
article in a collection out of WoS and Scopus
Language
English
Original Abstract
Abstract. Nebulizers are medical devices for inhalation treatment that create an aerosol from liquid drug formulation. The efficacy of the treatment is dependent on the particle size distribution (PSD) of generated aerosol. PSD can be influenced by the inhalation flow rate as well. Within the here-presented study PSD of aerosol generated by nebulizer Pari LC Sprint Star was measured by Phase Doppler Anemometry for inhalation flowrate of 8; 12; 20 and 40 l/min. The nebulized solution consisted of a liposomal system (20 %) from dipalmitoylfosfatidylcholine (DPPC), phosphatidic acid (PA) and cholesterol (Chol), and MiliQ – ultrapure water (80 %). Slight dependence of PSD on inhalation flow rate was identified. With the increasing flow rate, the particle size of generated aerosol is decreasing. However, the change of Dv50 with the measured flow rates was smaller than 1 μm. According to the results, the change in particle size induced by flow rate will not have a significant impact on drug delivery.
Keywords
Aerosol, particle size, nebulizuer, flow rate, liposom
Authors
MIŠÍK, O.; MALÝ, M.; CEJPEK, O.; SZABOVÁ, J.; LÍZAL, F.
Released
29. 11. 2022
Location
Dvůr Králové nad Labem
Pages count
4
BibTex
@inproceedings{BUT180626, author="Ondrej {Mišík} and Milan {Malý} and Ondřej {Cejpek} and Jana {Szabová} and František {Lízal}", title="Influence of inhalation flow rate on the particle size of liposomal carrier aerosol generated by the medical nebulizer", year="2022", pages="4", address="Dvůr Králové nad Labem" }