Publication detail

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

PENG, X. URSO, M. BALVAN, J. MASAŘÍK, M. PUMERA, M.

Original Title

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

Type

journal article in Web of Science

Language

English

Original Abstract

Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.

Keywords

Cargo Transportation; Micromachines; Micromotors; Photocatalysis; Tumor Cells

Authors

PENG, X.; URSO, M.; BALVAN, J.; MASAŘÍK, M.; PUMERA, M.

Released

25. 11. 2022

Publisher

WILEY-V C H VERLAG GMBH

Location

WEINHEIM

ISBN

1521-3773

Periodical

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Year of study

61

Number

48

State

Federal Republic of Germany

Pages count

8

URL

https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505

BibTex

@article{BUT181618,
  author="Xia {Peng} and Mario {Urso} and Jan {Balvan} and Michal {Masařík} and Martin {Pumera}",
  title="Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy",
  journal="ANGEWANDTE CHEMIE-INTERNATIONAL EDITION",
  year="2022",
  volume="61",
  number="48",
  pages="8",
  doi="10.1002/anie.202213505",
  issn="1521-3773",
  url="https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505"
}