Publication detail

Adsorption/desorption behavior of hyaluronic acid fragments at charged hydrophobic surface

ŠVECOVÁ, E. OSTATNÁ, V. FOJT, L. HERMANNOVÁ, M. VELEBNÝ, V. ONDREÁŠ, F.

Original Title

Adsorption/desorption behavior of hyaluronic acid fragments at charged hydrophobic surface

Type

journal article in Web of Science

Language

English

Original Abstract

This work reveals the growing potential of novel electrochemical methods that are applicable for polysaccharides. It was shown for the first time that the molecules of hyaluronic acid (HA) exhibit electrochemical response using phase-sensitive alternating current (AC) voltammetry in phase-out mode. Adsorption and desorption processes of HA fragments at a charged interface of mercury electrode were observed in buffered HA solutions. Electrostatic and hydrophobic manners of interactions were distinguished for native hyaluronan fragments in a wide electric potential range. The AC voltammetry response depended on the temperature, concentration, and length of HA chains. Results of this work open possibilities for further structural characterization of widely used HA fragments and understanding manners of interactions with charged hydrophobic surfaces that could be useful in the future for understanding HA interactions at biological levels.

Keywords

Alternating current voltammetry; Hyaluronic acid; Adsorption and desorption; Differential capacitance of the electrical double layer; Hanging mercury drop electrode

Authors

ŠVECOVÁ, E.; OSTATNÁ, V.; FOJT, L.; HERMANNOVÁ, M.; VELEBNÝ, V.; ONDREÁŠ, F.

Released

1. 2. 2022

Publisher

ELSEVIER SCI LTD

Location

OXFORD

ISBN

1879-1344

Periodical

Carbohydrate Polymers (electronic)

Year of study

277

Number

118831

State

United Kingdom of Great Britain and Northern Ireland

Pages count

8

URL

https://www.sciencedirect.com/science/article/pii/S0144861721012182?via%3Dihub

BibTex

@article{BUT182247,
  author="Eliška {Švecová} and Veronika {Ostatná} and Lukáš {Fojt} and Martina {Hermannová} and Vladimír {Velebný} and František {Ondreáš}",
  title="Adsorption/desorption behavior of hyaluronic acid fragments at charged hydrophobic surface",
  journal="Carbohydrate Polymers (electronic)",
  year="2022",
  volume="277",
  number="118831",
  pages="8",
  doi="10.1016/j.carbpol.2021.118831",
  issn="1879-1344",
  url="https://www.sciencedirect.com/science/article/pii/S0144861721012182?via%3Dihub"
}