Publication detail

In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

REBENDA, D. RANUŠA, M. ČÍPEK, P. TOROPITSYN, E. VRBKA, M.

Original Title

In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication

Type

journal article in Web of Science

Language

English

Original Abstract

Degradation of the articular cartilage (AC) structure due to osteoarthritis significantly influences its friction and lubrication mechanisms. Injection with exogenous hyaluronic acid (HA) is one of the ways to slow down the progress of these changes. The present paper aims to determine the effect of HA on the friction and lubrication processes of the synovial joint model. The main emphasis is placed on the effect of HA molecular weight (MW) on the coefficient of friction (COF) and the interactions between HA and other constituents of synovial fluid (SF). Frictional measurements between the AC surface and the glass were performed with simultaneous in situ observation of the contact zone by fluorescence microscopy. Using this methodology, a decrease in AC COF with an increase in the fluorescence intensity emitted from contact with HA was observed, while the phenomenon was found to be MW-dependent. These findings demonstrate that high-MW HA is more effective within a resumption of healthy AC lubrication due to a better adhesion to the AC surface.

Keywords

articular cartilage; friction; lubrication; hyaluronic acid; viscosupplementation

Authors

REBENDA, D.; RANUŠA, M.; ČÍPEK, P.; TOROPITSYN, E.; VRBKA, M.

Released

1. 1. 2023

Publisher

MDPI

Location

Basilej, Švýcarsko

ISBN

2075-4442

Periodical

Lubricants

Year of study

11

Number

1

State

Swiss Confederation

Pages count

15

URL

https://www.mdpi.com/2075-4442/11/1/12

Full text in the Digital Library

http://hdl.handle.net/11012/209205

BibTex

@article{BUT182273,
  author="David {Rebenda} and Matúš {Ranuša} and Pavel {Čípek} and Evgeniy {Toropitsyn} and Martin {Vrbka}",
  title="In Situ Observation of Hyaluronan Molecular Weight Effectiveness within Articular Cartilage Lubrication",
  journal="Lubricants",
  year="2023",
  volume="11",
  number="1",
  pages="15",
  doi="10.3390/lubricants11010012",
  issn="2075-4442",
  url="https://www.mdpi.com/2075-4442/11/1/12"
}