Publication detail

Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields

BOTZANOWSKI, B. DONAHUE, M. EJNEBY, M. GALLINA, A.L. NGOM, I. MISSEY, F. ACERBO, E. BYUN, D. CARRON, R. CASSARA, A.M. NEUFELD, E. JIRSA, V. OLOFSSON, P.S. GLOWACKI, E. WILLIAMSON, A.

Original Title

Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields

Type

journal article in Web of Science

Language

English

Original Abstract

Electrical stimulation of peripheral nerves is a cornerstone of bioelectronic medicine. Effective ways to accomplish peripheral nerve stimulation (PNS) noninvasively without surgically implanted devices are enabling for fundamental research and clinical translation. Here, it is demonstrated how relatively high-frequency sine-wave carriers (3 kHz) emitted by two pairs of cutaneous electrodes can temporally interfere at deep peripheral nerve targets. The effective stimulation frequency is equal to the offset frequency (0.5 - 4 Hz) between the two carriers. This principle of temporal interference nerve stimulation (TINS) in vivo using the murine sciatic nerve model is validated. Effective actuation is delivered at significantly lower current amplitudes than standard transcutaneous electrical stimulation. Further, how flexible and conformable on-skin multielectrode arrays can facilitate precise alignment of TINS onto a nerve is demonstrated. This method is simple, relying on the repurposing of existing clinically-approved hardware. TINS opens the possibility of precise noninvasive stimulation with depth and efficiency previously impossible with transcutaneous techniques.

Keywords

bioelectronic medicines; electrical stimulation; flexible electronics; neurostimulation; temporal interference; transcutaneous

Authors

BOTZANOWSKI, B.; DONAHUE, M.; EJNEBY, M.; GALLINA, A.L.; NGOM, I.; MISSEY, F.; ACERBO, E.; BYUN, D.; CARRON, R.; CASSARA, A.M.; NEUFELD, E.; JIRSA, V.; OLOFSSON, P.S.; GLOWACKI, E.; WILLIAMSON, A.

Released

1. 9. 2022

Publisher

WILEY

Location

HOBOKEN

ISBN

2192-2659

Periodical

Journal of Interconnection Networks

Year of study

11

Number

17

State

United Kingdom of Great Britain and Northern Ireland

Pages count

10

URL

https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200075

BibTex

@article{BUT182290,
  author="BOTZANOWSKI, B. and DONAHUE, M. and EJNEBY, M. and GALLINA, A.L. and NGOM, I. and MISSEY, F. and ACERBO, E. and BYUN, D. and CARRON, R. and CASSARA, A.M. and NEUFELD, E. and JIRSA, V. and OLOFSSON, P.S. and GLOWACKI, E. and WILLIAMSON, A.",
  title="Noninvasive Stimulation of Peripheral Nerves using Temporally-Interfering Electrical Fields",
  journal="Journal of Interconnection Networks",
  year="2022",
  volume="11",
  number="17",
  pages="10",
  doi="10.1002/adhm.202200075",
  issn="2192-2659",
  url="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202200075"
}