Publication detail

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

ORAL, Ç. USSIA, M. URSO, M. SALÁT, J. NOVOBILSKÝ, A. ŠTEFÁNIK, M. RŮŽEK, D. PUMERA, M.

Original Title

Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract

Type

journal article in Web of Science

Language

English

Original Abstract

Magnetic nanorobots offer wireless navigation capability in hard-to-reach areas of the human body for targeted therapy and diagnosis. Though in vivo imaging is required for guidance of the magnetic nanorobots toward the target areas, most of the imaging techniques are inadequate to reveal the potential locomotion routes. This work proposes the use of radiopaque magnetic nanorobots along with microcomputed tomography (microCT) for localized in vivo imaging applications. The nanorobots consist of a contrast agent, barium sulfate (BaSO4), magnetized by the decoration of magnetite (Fe3O4) particles. The magnetic features lead to actuation under rotating magnetic fields and enable precise navigation in a microfluidic channel used to simulate confined spaces of the body. In this channel, the intrinsic radiopacity of the nanorobots also provides the possibility to reveal the internal structures by X-ray contrast. Furthermore, in vitro analysis indicates nontoxicity of the nanorobots. In vivo experiments demonstrate localization of the nanorobots in a specific part of the gastrointestinal (GI) tract upon the influence of the magnetic field, indicating the efficient control even in the presence of natural peristaltic movements. The nanorobots reported here highlight that smart nanorobotic contrast agents can improve the current imaging-based diagnosis techniques by providing untethered controllability in vivo.

Keywords

computed tomography; gastrointestinal tract; magnetic actuation; medical imaging; nanomotors; nanoswimmers; tracking

Authors

ORAL, Ç.; USSIA, M.; URSO, M.; SALÁT, J.; NOVOBILSKÝ, A.; ŠTEFÁNIK, M.; RŮŽEK, D.; PUMERA, M.

Released

24. 3. 2023

Publisher

WILEY

Location

HOBOKEN

ISBN

2192-2640

Periodical

Advanced Healthcare Materials

Year of study

12

Number

8

State

United Kingdom of Great Britain and Northern Ireland

Pages count

9

URL

https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682

BibTex

@article{BUT182385,
  author="Çaǧatay Mert {Oral} and Martina {Ussia} and Mario {Urso} and Jiří {Salát} and Adam {Novobilský} and Michal {Štefánik} and Daniel {Růžek} and Martin {Pumera}",
  title="Radiopaque Nanorobots as Magnetically Navigable Contrast Agents for Localized In Vivo Imaging of the Gastrointestinal Tract",
  journal="Advanced Healthcare Materials",
  year="2023",
  volume="12",
  number="8",
  pages="9",
  doi="10.1002/adhm.202202682",
  issn="2192-2640",
  url="https://onlinelibrary.wiley.com/doi/10.1002/adhm.202202682"
}