Publication detail

N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: Interaction with a model pulmonary surfactant

SZABOVÁ, J. MRAVEC, F. MOKHTARI, M. LE BORGNE, R. KALINA, M. BERRET, J.

Original Title

N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: Interaction with a model pulmonary surfactant

Type

journal article in Web of Science

Language

English

Original Abstract

N,N,N-Trimethyl chitosan (TMC), a biocompatible and biodegradable derivative of chitosan, is currently used as a permeation enhancer to increase the translocation of drugs to the bloodstream in the lungs. This article discusses the effect of TMC on a mimetic pulmonary surfactant, Curosurf®, a low-viscosity lipid formulation administered to preterm infants with acute respiratory distress syndrome. Curosurf® exhibits a strong interaction with TMC, resulting in the formation of aggregates at electrostatic charge stoichiometry. At nanoscale, Curosurf® undergoes a profound reorganization of its lipid vesicles in terms of size and lamellarity. The initial micron-sized vesicles (average size 4.8 μm) give way to a froth-like network of unilamellar vesicles about 300 nm in size. Under such conditions, neutralization of the cationic charges by pulmonary surfactant may inhibit TMC permeation enhancer capacity, especially as electrostatic charge complexation is found at low TMC content. The permeation properties of pulmonary surfactant-neutralized TMC should then be evaluated for its applicability as a permeation enhancer for inhalation in the alveolar region.

Keywords

N,N,N-Trimethyl chitosan, Pulmonary surfactant, Electrostatic complexation, Polyelectrolytes, Lipid vesicles,Permeation enhancer

Authors

SZABOVÁ, J.; MRAVEC, F.; MOKHTARI, M.; LE BORGNE, R.; KALINA, M.; BERRET, J.

Released

1. 6. 2023

Publisher

Elsevier Science BV

Location

Holandsko

ISBN

0141-8130

Periodical

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Year of study

239

Number

June

State

Kingdom of the Netherlands

Pages from

1

Pages to

11

Pages count

11

URL

https://www.sciencedirect.com/science/article/pii/S0141813023011297

BibTex

@article{BUT183228,
  author="Jana {Szabová} and Filip {Mravec} and Mostafa {Mokhtari} and Rémi {Le Borgne} and Michal {Kalina} and Jean-François {Berret}",
  title="N,N,N-Trimethyl chitosan as a permeation enhancer for inhalation drug delivery: Interaction with a model pulmonary surfactant",
  journal="INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES",
  year="2023",
  volume="239",
  number="June",
  pages="1--11",
  doi="10.1016/j.ijbiomac.2023.124235",
  issn="0141-8130",
  url="https://www.sciencedirect.com/science/article/pii/S0141813023011297"
}