Publication detail

Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay

GAREHBAGHI, S. ASHRAFI, A. ADAM, V. RICHTERA, L.

Original Title

Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay

Type

journal article in Web of Science

Language

English

Original Abstract

Gold nanozymes (GNZs) have been widely used in biosensing and bioassay due to their interesting catalytic activities that enable the substitution of natural enzyme. This review explains different catalytic activities of GNZs that can be achieved by applying different modifications to their surface. The role of Gold nanoparticles (GNPs) in mimicking oxidoreductase, helicase, phosphatase were introduced. Moreover, the effect of surface properties and modifications on each catalytic activity was thoroughly discussed. The application of GNZs in biosensing and bioassay was classified in five categories based on the combination of the enzyme like activities and enhancing/ inhibition of the catalytic activities in presence of the target analyte/s that is realized by proper surface modification engineering. These categories include catalytic activity enhancer, reversible catalytic activity inhibitor, binding selectivity enhancer, agglomeration base, and multienzyme like activity, which are explained and exemplified in this review. It also gives examples of those modifications that enable the application of GNZs for in vivo biosensing and bioassays.

Keywords

Gold nanozyme; Catalytic activity; Surface modification; Biosensing and bioassay

Authors

GAREHBAGHI, S.; ASHRAFI, A.; ADAM, V.; RICHTERA, L.

Released

1. 6. 2023

Publisher

Elsevier

Location

AMSTERDAM

ISBN

2590-0064

Periodical

Materials Today Bio

Year of study

20

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages count

16

URL

https://www.sciencedirect.com/science/article/pii/S2590006423001163

Full text in the Digital Library

http://hdl.handle.net/11012/213828

BibTex

@article{BUT183975,
  author="Sanam {Garehbaghi} and Amirmansoor {Ashrafi} and Vojtěch {Adam} and Lukáš {Richtera}",
  title="Surface modification strategies and the functional mechanisms of gold nanozyme in biosensing and bioassay",
  journal="Materials Today Bio",
  year="2023",
  volume="20",
  number="1",
  pages="16",
  doi="10.1016/j.mtbio.2023.100656",
  issn="2590-0064",
  url="https://www.sciencedirect.com/science/article/pii/S2590006423001163"
}