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HEGER, R. ZINKOVSKA, N. TRUDIČOVÁ, M. KADLEC, M. PEKAŘ, M. SMILEK, J.
Original Title
Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels
Type
journal article in Web of Science
Language
English
Original Abstract
Transport properties are one of the most crucial assets of hydrogel samples, influencing their main application potential, i.e., as drug carriers. Depending on the type of drug or the application itself, it is very important to be able to control these transport properties in an appropriate manner. This study seeks to modify these properties by adding amphiphiles, specifically lecithin. Through its self-assembly, lecithin modifies the inner structure of the hydrogel, which affects its properties, especially the transport ones. In the proposed paper, these properties are studied mainly using various probes (organic dyes) to effectively simulate drugs in simple release diffusion experiments controlled by UV-Vis spectrophotometry. Scanning electron microscopy was used to help characterize the diffusion systems. The effects of lecithin and its concentrations, as well as the effects of variously charged model drugs, were discussed. Lecithin decreases the values of the diffusion coefficient independently of the dye used and the type of crosslinking. The ability to influence transport properties is better observed in xerogel samples. The results, complementing previously published conclusions, showed that lecithin can alter a hydrogel’s structure and therefore its transport properties.
Keywords
diffusion; extracellular matrix; hydrogel; lecithin; model drugs; scanning electron microscopy; transport properties
Authors
HEGER, R.; ZINKOVSKA, N.; TRUDIČOVÁ, M.; KADLEC, M.; PEKAŘ, M.; SMILEK, J.
Released
27. 4. 2023
Publisher
MDPI
Location
Basel
ISBN
2310-2861
Periodical
Gels
Year of study
9
Number
5
State
Swiss Confederation
Pages count
18
URL
https://www.mdpi.com/2310-2861/9/5/367
Full text in the Digital Library
http://hdl.handle.net/11012/213544
BibTex
@article{BUT184017, author="Richard {Heger} and Natalia {Zinkovska} and Monika {Trudičová} and Martin {Kadlec} and Miloslav {Pekař} and Jiří {Smilek}", title="Lecithin as an Effective Modifier of the Transport Properties of Variously Crosslinked Hydrogels", journal="Gels", year="2023", volume="9", number="5", pages="18", doi="10.3390/gels9050367", issn="2310-2861", url="https://www.mdpi.com/2310-2861/9/5/367" }