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Publication detail
Vaishali Pankaj, Inderjeet Bhogal, Sudeep Roy
Original Title
“In silico approaches to find potential HDAC8 antagonist in treatment of breast cancer”
Type
presentation, poster
Language
English
Original Abstract
Histone deacetylases (HDACs) are the key enzymes that are involved in the deacetylation of histone and non-histone proteins. HDACs aberrant expression and activity is linked with the regulation of various genes involved in cancer initiation and progression. Class I HDAC8 has been reported to be overexpressed in breast cancer and induces the estrogen receptor (ER), leading to breast cancer formation. This gives rise to find potential HDAC antagonist that can inhibit cell proliferation and apoptosis of cancer cells. In the current study, the focus is to find potential and novel HDAC inhibitor that has therapeutic effects against cancer using computational methods.
Keywords
Histone deacetylases (HDACs), antagonist, Breast cancer, molecular modelling
Authors
Released
29. 8. 2023
Location
Eindhoven, Netherlands
Pages from
1
Pages to
2
Pages count
BibTex
@misc{BUT184537, author="Vaishali {Pankaj} and Inderjeet {Bhogal} and Sudeep {Roy}", title="“In silico approaches to find potential HDAC8 antagonist in treatment of breast cancer”", booktitle="20th IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology", year="2023", pages="1--2", address="Eindhoven, Netherlands", note="presentation, poster" }