Publication detail

Antibacterial copper nanoparticles loaded pH-responsive nanocapsules for the treatment of infectious wounds

POLÁKOVÁ, V. FOHLEROVÁ, Z. VOJTOVÁ, L.

Original Title

Antibacterial copper nanoparticles loaded pH-responsive nanocapsules for the treatment of infectious wounds

Type

abstract

Language

English

Original Abstract

Infected burns and chronic wounds are extremely painful issues that can progress to severe complications, even to sepsis. In many cases, traditionally used antibiotics are ineffective due to the secondary resistance of many bacteria strains. Recently, the development of inorganic nanoparticles loaded smart nanocomplexes against bacteria strains with antibiotic resistance have got more attention. In the past years, many drug and nanoparticle delivery systems with pH controlled release in acidic pH region have been developed for cancer treatment. However, there have been only a few attempts to design a pH triggered delivery system with release in alkaline pH environment of the infectious wound. In this project, we synthesize smart copper nanoparticles (CuNPs) loaded poly(lactic acid) capsules. These capsules release antibacterial CuNPs in the response to alkaline pH of the infectious environment on the principle of electrostatic repulsion. Nanoparticles were synthesized by chemical reduction and stabilized with chitosan of both, low (LMw) and medium molecular weight (MMw). Stabilized nanoparticles were encapsulated in pH responsive capsules made of poly(lactic acid), a biodegradable polyacid widely used in medicine. The synthesized nanoparticles and capsules were characterized by transmission electron microscopy, dynamic light scattering, and UV-VIS spectroscopy. Finally, encapsulated CuNPs can be loaded into various scaffolds, wound dressings, or hydrogels. Preliminary experiments of CuNPs synthesis compared LMw and MMw chitosan as a stabilizing agent. MMw chitosan coated CuNPs formed particles with an average radius of 203.9 nm, whereas LMw chitosan formed particles with an average radius of 170.4 nm. LMw chitosan particles formed fewer clusters, which can be advantageous for the subsequent encapsulation procedure.

Keywords

Copper nanoparticles, polylactic acid, encapsulation, nanoscience, biomaterials, infectious wound, pH-controlled, controlled release

Authors

POLÁKOVÁ, V.; FOHLEROVÁ, Z.; VOJTOVÁ, L.

Released

20. 8. 2023

Publisher

Materials Research Society of Serbia

Location

Belgrade

ISBN

978-86-919111-8-8

Book

THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023 Program and Book of Abstracts Herceg Novi, September 4-8, 2023

Pages from

101

Pages to

101

Pages count

183

URL

https://mrs-serbia.org.rs/index.php/book-of-abstracts-2023

BibTex

@misc{BUT184661,
  author="Veronika {Poláková} and Zdenka {Fohlerová} and Lucy {Vojtová}",
  title="Antibacterial copper nanoparticles loaded pH-responsive nanocapsules for the treatment of infectious wounds",
  booktitle="THE TWENTY-FOURTH ANNUAL CONFERENCE YUCOMAT 2023
Program and Book of Abstracts

Herceg Novi, September 4-8, 2023",
  year="2023",
  pages="101--101",
  publisher="Materials Research Society of Serbia",
  address="Belgrade",
  isbn="978-86-919111-8-8",
  url="https://mrs-serbia.org.rs/index.php/book-of-abstracts-2023",
  note="abstract"
}