Publication result detail

CHANGES IN CELLULAR STIFFNESS RELATED TO CANCER-INDUCED CYTOSKELETON REORGANIZATION

JADRNÁ, L.; GUMULEC, J.; BURŠA, J.

Original Title

CHANGES IN CELLULAR STIFFNESS RELATED TO CANCER-INDUCED CYTOSKELETON REORGANIZATION

English Title

CHANGES IN CELLULAR STIFFNESS RELATED TO CANCER-INDUCED CYTOSKELETON REORGANIZATION

Type

Paper in proceedings outside WoS and Scopus

Original Abstract

Cellular mechanics undergo complex changes during cancer progression in parallel with metabolic reprogramming due to altered demands on its motility. As the cytoskeleton forms a major part of cellular stiffness, this study focuses mainly on exploring cytoskeletal changes in cancer cells and evaluating their direct impact on cellular stiffness. However, the association between cellular stiffness and tumor cell aggressiveness is not straightforward and results vary depending on tumor type. The main aim of this study was to explore the relationship between the altered inner structural arrangement and cell aggressivity in prostate cancer cells using a combination of laboratory and computational methods.

English abstract

Cellular mechanics undergo complex changes during cancer progression in parallel with metabolic reprogramming due to altered demands on its motility. As the cytoskeleton forms a major part of cellular stiffness, this study focuses mainly on exploring cytoskeletal changes in cancer cells and evaluating their direct impact on cellular stiffness. However, the association between cellular stiffness and tumor cell aggressiveness is not straightforward and results vary depending on tumor type. The main aim of this study was to explore the relationship between the altered inner structural arrangement and cell aggressivity in prostate cancer cells using a combination of laboratory and computational methods.

Keywords

CELLULAR STIFFNESS; CANCER-INDUCED CYTOSKELETON; CELLULAR MECHANICS

Key words in English

CELLULAR STIFFNESS; CANCER-INDUCED CYTOSKELETON; CELLULAR MECHANICS

Authors

JADRNÁ, L.; GUMULEC, J.; BURŠA, J.

Released

09.07.2023

Publisher

ESB

Location

Maastricht

Book

ESB 2023 BOOK OF ABSTRACTS

Pages count

1

URL

https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf

BibTex

@inproceedings{BUT184929,
  author="Lucie {Jadrná} and Jaromír {Gumulec} and Jiří {Burša}",
  title="CHANGES IN CELLULAR STIFFNESS RELATED TO CANCER-INDUCED CYTOSKELETON REORGANIZATION",
  booktitle="ESB 2023 BOOK OF ABSTRACTS",
  year="2023",
  number="28",
  pages="1",
  publisher="ESB",
  address="Maastricht",
  url="https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf"
}