Publication detail

The first solid-state route to luminescent Au(I)-glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10-12(SG)10-12 nanoclusters for application in cancer radiotheraphy

DEÁK, A. SZABÓ, P. BEDNAŘÍKOVÁ, V. CIHLÁŘ, J. DEMETER, A. REMEŠOVÁ, M. COLACINO, E. ČELKO, L.

Original Title

The first solid-state route to luminescent Au(I)-glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10-12(SG)10-12 nanoclusters for application in cancer radiotheraphy

Type

journal article in Web of Science

Language

English

Original Abstract

There is still a need for synthetic approaches that are much faster, easier to scale up, more robust and efficient for generating gold(I)-thiolates that can be easily converted into gold-thiolate nanoclusters. Mechanochemical methods can offer significantly reduced reaction times, increased yields and straightforward recovery of the product, compared to the solution-based reactions. For the first time, a new simple, rapid and efficient mechanochemical redox method in a ball-mill was developed to produce the highly luminescent, pH-responsive Au(I)-glutathionate, [Au(SG)]( n ). The efficient productivity of the mechanochemical redox reaction afforded orange luminescent [Au(SG)]( n ) in isolable amounts (mg scale), usually not achieved by more conventional methods in solution. Then, ultrasmall oligomeric Au10-12(SG)(10-12) nanoclusters were prepared by pH-triggered dissociation of [Au(SG)]( n ). The pH-stimulated dissociation of the Au(I)-glutathionate complex provides a time-efficient synthesis of oligomeric Au10-12(SG)(10-12) nanoclusters, it avoids high-temperature heating or the addition of harmful reducing agent (e.g., carbon monoxide). Therefore, we present herein a new and eco-friendly methodology to access oligomeric glutathione-based gold nanoclusters, already finding applications in biomedical field as efficient radiosensitizers in cancer radiotherapy.

Keywords

bioactive molecules; gold nanocluster; gold thiolate; glutathione; mechanochemistry

Authors

DEÁK, A.; SZABÓ, P.; BEDNAŘÍKOVÁ, V.; CIHLÁŘ, J.; DEMETER, A.; REMEŠOVÁ, M.; COLACINO, E.; ČELKO, L.

Released

5. 6. 2023

Publisher

Frontiers Media

Location

LAUSANNE

ISBN

2296-2646

Periodical

Frontiers in Chemistry

Year of study

11

Number

6

State

Swiss Confederation

Pages count

11

URL

https://www.frontiersin.org/articles/10.3389/fchem.2023.1178225/full

Full text in the Digital Library

http://hdl.handle.net/11012/214436

BibTex

@article{BUT185020,
  author="Andréa {Deák} and Pál T. {Szabó} and Vendula {Bednaříková} and Jaroslav {Cihlář} and Attila {Demeter} and Michaela {Remešová} and Evelina {Colacino} and Ladislav {Čelko}",
  title="The first solid-state route to luminescent Au(I)-glutathionate and its pH-controlled transformation into ultrasmall oligomeric Au10-12(SG)10-12 nanoclusters for application in cancer radiotheraphy",
  journal="Frontiers in Chemistry",
  year="2023",
  volume="11",
  number="6",
  pages="11",
  doi="10.3389/fchem.2023.1178225",
  issn="2296-2646",
  url="https://www.frontiersin.org/articles/10.3389/fchem.2023.1178225/full"
}