Publication detail

Aerogel-Based Materials in Bone and Cartilage Tissue Engineering-A Review with Future Implications

LÁZÁR, I. ČELKO, L. MENELAOU, M.

Original Title

Aerogel-Based Materials in Bone and Cartilage Tissue Engineering-A Review with Future Implications

Type

journal article in Web of Science

Language

English

Original Abstract

Aerogels are fascinating solid materials known for their highly porous nanostructure and exceptional physical, chemical, and mechanical properties. They show great promise in various technological and biomedical applications, including tissue engineering, and bone and cartilage substitution. To evaluate the bioactivity of bone substitutes, researchers typically conduct in vitro tests using simulated body fluids and specific cell lines, while in vivo testing involves the study of materials in different animal species. In this context, our primary focus is to investigate the applications of different types of aerogels, considering their specific materials, microstructure, and porosity in the field of bone and cartilage tissue engineering. From clinically approved materials to experimental aerogels, we present a comprehensive list and summary of various aerogel building blocks and their biological activities. Additionally, we explore how the complexity of aerogel scaffolds influences their in vivo performance, ranging from simple single-component or hybrid aerogels to more intricate and organized structures. We also discuss commonly used formulation and drying methods in aerogel chemistry, including molding, freeze casting, supercritical foaming, freeze drying, subcritical, and supercritical drying techniques. These techniques play a crucial role in shaping aerogels for specific applications. Alongside the progress made, we acknowledge the challenges ahead and assess the near and far future of aerogel-based hard tissue engineering materials, as well as their potential connection with emerging healing techniques.

Keywords

aerogel; tissue engineering; artificial bone substitution; in vitro and in vivo bioactivity; biodegradation; cartilage regeneration; scaffold; osteogenesis; simulated body fluids; immortalized cell lines

Authors

LÁZÁR, I.; ČELKO, L.; MENELAOU, M.

Released

13. 9. 2023

Publisher

MDPI

Location

BASEL

ISBN

2310-2861

Periodical

Gels

Year of study

9

Number

9

State

Swiss Confederation

Pages count

40

URL

https://www.mdpi.com/2310-2861/9/9/746

Full text in the Digital Library

http://hdl.handle.net/11012/214453

BibTex

@article{BUT185034,
  author="István {Lázár} and Ladislav {Čelko} and Melita {Menelaou}",
  title="Aerogel-Based Materials in Bone and Cartilage Tissue Engineering-A Review with Future Implications",
  journal="Gels",
  year="2023",
  volume="9",
  number="9",
  pages="40",
  doi="10.3390/gels9090746",
  issn="2310-2861",
  url="https://www.mdpi.com/2310-2861/9/9/746"
}