Publication detail

INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION

EZATI, M. SAADATI, A. CAO, H. ZUMBERG, I. ČMIEL, V. LUKAS, R.

Original Title

INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION

Type

conference paper

Language

English

Original Abstract

Nano-sized exosomes are essential for intercellular communication, especially in cancer biology. Human produces exosomes that may modulate the tumor microenvironment and cellular behavior. This study examines how human prostate cancer cells (PC3) derived exosomes affect fibroblast proliferation and migration. Ultracentrifugation isolated exosomes from PC3 cell culture supernatants, which were characterized by confocal and transmission electron microscopy (TEM). Fibroblast cells were exposed to these PC3-derived exosomes. MTT [3–(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazoliumbromide] was used to measure fibroblast proliferation, while another assay measured migration. PC3 exosomes appear to boost fibroblast proliferation and migration. Investigations into the molecular mechanisms behind these observations are ongoing. The study shows that PC3-derived exosomes can regulate fibroblast proliferation and migration. This study illuminates the effects of cancer cell-derived exosomes on cellular interactions and therapeutic potential.

Keywords

Human prostate cancer cell (PC3), exosomes, fibroblast proliferation and migration

Authors

EZATI, M.; SAADATI, A.; CAO, H.; ZUMBERG, I.; ČMIEL, V.; LUKAS, R.

Released

13. 12. 2023

Publisher

TANGER Ltd.

Location

Ostrava, Czech Republic

ISBN

978-80-88365-15-0

Book

CONFERENCE PROCEEDINGS - NANOCON 2023

Edition

1

ISBN

2694-930X

Periodical

Proceedings 12th International Conference on Nanomaterials - Research & Application

State

Czech Republic

Pages from

268

Pages to

272

Pages count

5

URL

https://doi.org/10.37904/nanocon.2023.4802

BibTex

@inproceedings{BUT185088,
  author="Masoumeh {Ezati} and Arezoo {Saadati} and Hoang-Anh {Cao} and Inna {Zumberg} and Vratislav {Čmiel} and Richtera {Lukas}",
  title="INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION",
  booktitle="CONFERENCE PROCEEDINGS - NANOCON 2023",
  year="2023",
  series="1",
  journal="Proceedings 12th International Conference on Nanomaterials - Research & Application",
  pages="5",
  publisher="TANGER Ltd.",
  address="Ostrava, Czech Republic",
  doi="10.37904/nanocon.2023.4802",
  isbn="978-80-88365-15-0",
  issn="2694-930X",
  url="https://doi.org/10.37904/nanocon.2023.4802"
}