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MUÑOZ MARTIN, J. OLIVER DE LA CRUZ, J. FORTE, G. PUMERA, M.
Original Title
Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion
Type
journal article in Web of Science
Language
English
Original Abstract
This work examines the suitability of graphene-based 3D-printed nanocomposite bioelectronics as innovative systems to in situ monitor and evaluate both breast cancer cell adhesion and the chemosensitivity of anti-cancer drugs. With this aim, 3D-printed nanocomposite graphene electrodes (3D-nGEs) -made of a commercially available graphene/polylactic acid filament- have been covalently biofunctionalized with an extracellular matrix protein (i.e., fibronectin) by exploiting the carbon reactivity of 3D-nGEs. The specificity and selectivity of the developed electrochemical system to monitor breast cancer cell adhesion has been tested via electrochemical impedance spectroscopy (EIS). Importantly, the resulting 3D-printed bioelectronic system displayed excellent accuracy for the rapid screening of anti-cancer drugs, which exactly corresponded with the results achieved by the standard optical method, while having the advantage of employing a label-free approach. In light of the current state-of-the-art in the field, this proof-of-concept connects electronics to biological systems within 3D printing technology, providing the bases for the sustainable and cost-effective manufacturing of graphene-based 3D-printed nanocomposite bioelectronics to simulate in vivo microenvironments using in situ and real time electronic output signals.
Keywords
3D-printed electrodes; Breast cancer cells; Electrochemical impedance spectroscopy; Anti -cancer drugs; Additive manufacturing
Authors
MUÑOZ MARTIN, J.; OLIVER DE LA CRUZ, J.; FORTE, G.; PUMERA, M.
Released
15. 4. 2023
Publisher
ELSEVIER ADVANCED TECHNOLOGY
Location
OXFORD
ISBN
1873-4235
Periodical
BIOSENSORS & BIOELECTRONICS
Year of study
226
Number
115113
State
Kingdom of the Netherlands
Pages count
8
URL
https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0956566323000556
BibTex
@article{BUT186926, author="Jose Maria {Muñoz Martin} and Jorge {Oliver De La Cruz} and Giancarlo {Forte} and Martin {Pumera}", title="Graphene-based 3D-Printed nanocomposite bioelectronics for monitoring breast cancer cell adhesion", journal="BIOSENSORS & BIOELECTRONICS", year="2023", volume="226", number="115113", pages="8", doi="10.1016/j.bios.2023.115113", issn="1873-4235", url="https://www-sciencedirect-com.ezproxy.lib.vutbr.cz/science/article/pii/S0956566323000556" }