Publication detail

From Natural to Artificial Biorecognition Elements: From Antibodies to Molecularly Imprinted Polymers

BEZDĚKOVÁ, J. RÝPAR, T. VLČNOVSKÁ, M. VACULOVIČOVÁ, M. MACKA, M.

Original Title

From Natural to Artificial Biorecognition Elements: From Antibodies to Molecularly Imprinted Polymers

Type

book chapter

Language

English

Original Abstract

While developments in the field of molecular recognition elements enabled the progress in the creation of novel assays and sensors, and they also have an enormous potential for use in pharmaceutical industries and medicine. Currently, the most common recognition elements are antibodies, which are routinely used in affinity technologies and biomedicine due to their ability to specifically recognize a target molecule (the antigen). Nevertheless, antibody-based methods still face several obstacles, especially in their extremely high production costs that limit their widespread application as therapeutics. However, their limitations lead to the development of other, completely novel recognition components that are able to overcome the limitations of biological macromolecules. Among very promising areas appear to be aptamers, which are synthetic short single-stranded chains of nucleic acids that are able to bind to protein targets, and molecularly imprinted polymers that are synthetic polymers with recognition ability. In this chapter, a critical comparison of these recognition elements is offered, and their suitability for the pharmaceutical or medicine area is discussed in detail.

Keywords

Bioanalysis; Biomedical; Bioreceptors; Molecularly imprinted polymers

Authors

BEZDĚKOVÁ, J.; RÝPAR, T.; VLČNOVSKÁ, M.; VACULOVIČOVÁ, M.; MACKA, M.

Released

1. 1. 2021

ISBN

978-9-8116-2782-8

Book

BioSensing, Theranostics, and Medical Devices: from Laboratory to Point-of-Care Testing

Pages from

185

Pages to

206

Pages count

11

URL

https://www.scopus.com/record/display.uri?eid=2-s2.0-85152813166&origin=inward&txGid=51ac69bd773e3ef0bc626cd6aaaaaf07

BibTex

@inbook{BUT187538,
  author="Jaroslava {Bezděková} and Tomáš {Rýpar} and Marcela {Vlčnovská} and Markéta {Vaculovičová} and Miroslav {Macka}",
  title="From Natural to Artificial Biorecognition Elements: From Antibodies to Molecularly Imprinted Polymers",
  booktitle="BioSensing, Theranostics, and Medical Devices: from Laboratory to Point-of-Care Testing",
  year="2021",
  pages="185--206",
  doi="10.1007/978-981-16-2782-8\{_}8",
  isbn="978-9-8116-2782-8",
  url="https://www.scopus.com/record/display.uri?eid=2-s2.0-85152813166&origin=inward&txGid=51ac69bd773e3ef0bc626cd6aaaaaf07"
}