Publication detail

Photo-Chemical Stimulation of Neurons with Organic Semiconductors

Savva, A. Hama, A. Herrera-López, G. Schmidt, T. Migliaccio, L. Steiner, N. Kawan, M. Fiumelli, H. Magistretti, PJ. Mcculloch, I. Baran, D. Gasparini, N. Schindl, R. Glowacki, ED. Inal, S.

Original Title

Photo-Chemical Stimulation of Neurons with Organic Semiconductors

Type

journal article in Web of Science

Language

English

Original Abstract

Recent advances in light-responsive materials enabled the development of devices that can wirelessly activate tissue with light. Here it is shown that solution-processed organic heterojunctions can stimulate the activity of primary neurons at low intensities of light via photochemical reactions. The p-type semiconducting polymer PDCBT and the n-type semiconducting small molecule ITIC (a non-fullerene acceptor) are coated on glass supports, forming a p-n junction with high photosensitivity. Patch clamp measurements show that low-intensity white light is converted into a cue that triggers action potentials in primary cortical neurons. The study shows that neat organic semiconducting p-n bilayers can exchange photogenerated charges with oxygen and other chemical compounds in cell culture conditions. Through several controlled experimental conditions, photo-capacitive, photo-thermal, and direct hydrogen peroxide effects on neural function are excluded, with photochemical delivery being the possible mechanism. The profound advantages of low-intensity photo-chemical intervention with neuron electrophysiology pave the way for developing wireless light-based therapy based on emerging organic semiconductors. Highly photosensitive, organic p-n junctions stimulate primary neurons via photochemical reactions, when illuminated with low-intensity light. The profound advantages of low-intensity, photo-chemical intervention with neuron electrophysiology, pave the way for developing wireless, light therapy, based on emerging organic semiconductors.image

Keywords

non-fullerene acceptors; organic bioelectronics; photo-stimulation

Authors

Savva, A.; Hama, A.; Herrera-López, G.; Schmidt, T.; Migliaccio, L.; Steiner, N.; Kawan, M.; Fiumelli, H.; Magistretti, PJ.; Mcculloch, I.; Baran, D.; Gasparini, N.; Schindl, R.; Glowacki, ED.; Inal, S.

Released

3. 11. 2023

Publisher

WILEY

Location

HOBOKEN

ISBN

2198-3844

Periodical

Advanced Science

Year of study

10

Number

31

State

United States of America

Pages count

11

URL

https://onlinelibrary.wiley.com/doi/10.1002/advs.202300473

BibTex

@article{BUT187785,
  author="Savva, A. and Hama, A. and Herrera-López, G. and Schmidt, T. and Migliaccio, L. and Steiner, N. and Kawan, M. and Fiumelli, H. and Magistretti, PJ. and Mcculloch, I. and Baran, D. and Gasparini, N. and Schindl, R. and Glowacki, ED. and Inal, S.",
  title="Photo-Chemical Stimulation of Neurons with Organic Semiconductors",
  journal="Advanced Science",
  year="2023",
  volume="10",
  number="31",
  pages="11",
  doi="10.1002/advs.202300473",
  issn="2198-3844",
  url="https://onlinelibrary.wiley.com/doi/10.1002/advs.202300473"
}