Publication detail

Impedance Rhythms in Human Limbic System

Mivalt, F. Kremen, V. Sladky, V. Cui, J. Gregg, N. Balzekas, I. Marks, V. St Louis, E. Croarkin, E. Lundstrom, B. Nelson, N. Kim, J. Hermes, D. Messina, S. Worrell, S. Richner, T. Brinkmann, B. Denison, T. Miller, K. Van Gompel, J. Stead, M. Worrell, G.

Original Title

Impedance Rhythms in Human Limbic System

Type

journal article in Web of Science

Language

English

Original Abstract

he impedance is a fundamental electrical property of brain tissue, playing a crucial role in shaping the characteristics of local field potentials, the extent of ephaptic coupling, and the volume of tissue activated by externally applied electrical brain stimulation. We tracked brain impedance, sleep–wake behavioral state, and epileptiform activity in five people with epilepsy living in their natural environment using an investigational device. The study identified impedance oscillations that span hours to weeks in the amygdala, hippocampus, and anterior nucleus thalamus. The impedance in these limbic brain regions exhibit multiscale cycles with ultradian (;1.5–1.7 h), circadian (;21.6–26.4 h), and infradian (;20–33 d) periods. The ultradian and circadian period cycles are driven by sleep–wake state transitions between wakefulness, nonrapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. Limbic brain tissue impedance reaches a minimum value in NREM sleep, intermediate values in REM sleep, and rises through the day during wakefulness, reaching a maximum in the early evening before sleep onset. Infradian (;20–33 d) impedance cycles were not associated with a distinct behavioral correlate. Brain tissue impedance is known to strongly depend on the extracellular space (ECS) volume, and the findings reported here are consistent with sleep–wake–dependent ECS volume changes recently observed in the rodent cortex related to the brain glymphatic system. We hypothesize that human limbic brain ECS changes during sleep–wake state transitions underlie the observed multiscale impedance cycles. Impedance is a simple electrophysiological biomarker that could prove useful for tracking ECS dynamics in human health, disease, and therapy.

Keywords

brain impedance; circadian rhythm; extracellular space; implantable neural stimulators; long-term data; sleep

Authors

Mivalt, F.; Kremen, V.; Sladky, V.; Cui, J.; Gregg, N.; Balzekas, I.; Marks, V.; St Louis, E.; Croarkin, E.; Lundstrom, B.; Nelson, N.; Kim, J.; Hermes, D.; Messina, S.; Worrell, S.; Richner, T.; Brinkmann, B.; Denison, T.; Miller, K.; Van Gompel, J.; Stead, M.; Worrell, G.

Released

20. 9. 2023

Publisher

Society for Neuroscience

ISBN

0270-6474

Periodical

JOURNAL OF NEUROSCIENCE

Year of study

43

Number

39

State

United States of America

Pages from

6653

Pages to

6666

Pages count

14

URL

https://www.jneurosci.org/content/43/39/6653.long

BibTex

@article{BUT188113,
  author="Mivalt, F. and Kremen, V. and Sladky, V. and Cui, J. and Gregg, N. and Balzekas, I. and Marks, V. and St Louis, E. and Croarkin, E. and Lundstrom, B. and Nelson, N. and Kim, J. and Hermes, D. and Messina, S. and Worrell, S. and Richner, T. and Brinkmann, B. and Denison, T. and Miller, K. and Van Gompel, J. and Stead, M. and Worrell, G.",
  title="Impedance Rhythms in Human Limbic System",
  journal="JOURNAL OF NEUROSCIENCE",
  year="2023",
  volume="43",
  number="39",
  pages="6653--6666",
  doi="10.1523/JNEUROSCI.0241-23.2023",
  issn="0270-6474",
  url="https://www.jneurosci.org/content/43/39/6653.long"
}