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JAGOŠ, J. KOHÚT, J. NOVOTNÝ, T. KŘIVKA, T. HÁJEK, P. FORMÁNEK, M. LISICKÝ, O. BURŠA, J.
Original Title
In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs
Type
journal article in Web of Science
Language
English
Original Abstract
Background and objectives: Age-related arterial stiffening increases peripheral resistance and decreases arterial distensibility, thus contributing to hypertension, an important risk factor of atherosclerosis. It causes abnormal blood flow, endothelial dysfunction, higher pulse wave velocity, and consequently elevated pressure wave amplitude. Methods: This paper presents the influence of these changes via multiscale 3D-0D transient computational fluid dynamics simulations of blood flow in five patient-specific geometries of human carotid bifurcation using archetypal flow waveforms for young and old subjects. Results: The proposed model shows a significant decrease in the time-averaged wall shear stress (TAWSS) for the old archetypal flow waveform. This is in good agreement with clinical data on a straight segment of common carotid arteries available for young and old subjects. Moreover, our study showed that the decrease of areaaveraged TAWSS related to the old flow waveform is much more pronounced (2.5 divided by 4.5 times higher) at risk areas (areas showing TAWSS below its threshold value of 0.48 Pa) than in straight segments commonly considered in clinical studies. Conclusions: Since arterial stiffness can be lowered through long-term usage of any of the five basic groups of antihypertensives, possible benefits of such medical therapy could be not only lowering blood pressure and peripheral resistance but also in increasing the TAWSS and thus attenuating an important mechanism of the atherosclerotic process.
Keywords
Multiscale flow simulations; Patient-specific model; Carotid artery; Atherosclerosis; Parameter optimization; Antihypertensives
Authors
JAGOŠ, J.; KOHÚT, J.; NOVOTNÝ, T.; KŘIVKA, T.; HÁJEK, P.; FORMÁNEK, M.; LISICKÝ, O.; BURŠA, J.
Released
11. 1. 2024
Publisher
ELSEVIER IRELAND LTD
Location
CLARE
ISBN
1872-7565
Periodical
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
Year of study
245
Number
2024
State
Kingdom of the Netherlands
Pages from
108016-1
Pages to
108016-10
Pages count
10
URL
https://www.sciencedirect.com/science/article/pii/S0169260724000129