Publication detail

In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs

JAGOŠ, J. KOHÚT, J. NOVOTNÝ, T. KŘIVKA, T. HÁJEK, P. FORMÁNEK, M. LISICKÝ, O. BURŠA, J.

Original Title

In silico hemodynamical simulations show additional benefits of artery wall softening induced by antihypertensive drugs

Type

journal article in Web of Science

Language

English

Original Abstract

Background and objectives: Age-related arterial stiffening increases peripheral resistance and decreases arterial distensibility, thus contributing to hypertension, an important risk factor of atherosclerosis. It causes abnormal blood flow, endothelial dysfunction, higher pulse wave velocity, and consequently elevated pressure wave amplitude. Methods: This paper presents the influence of these changes via multiscale 3D-0D transient computational fluid dynamics simulations of blood flow in five patient-specific geometries of human carotid bifurcation using archetypal flow waveforms for young and old subjects. Results: The proposed model shows a significant decrease in the time-averaged wall shear stress (TAWSS) for the old archetypal flow waveform. This is in good agreement with clinical data on a straight segment of common carotid arteries available for young and old subjects. Moreover, our study showed that the decrease of areaaveraged TAWSS related to the old flow waveform is much more pronounced (2.5 divided by 4.5 times higher) at risk areas (areas showing TAWSS below its threshold value of 0.48 Pa) than in straight segments commonly considered in clinical studies. Conclusions: Since arterial stiffness can be lowered through long-term usage of any of the five basic groups of antihypertensives, possible benefits of such medical therapy could be not only lowering blood pressure and peripheral resistance but also in increasing the TAWSS and thus attenuating an important mechanism of the atherosclerotic process.

Keywords

Multiscale flow simulations; Patient-specific model; Carotid artery; Atherosclerosis; Parameter optimization; Antihypertensives

Authors

JAGOŠ, J.; KOHÚT, J.; NOVOTNÝ, T.; KŘIVKA, T.; HÁJEK, P.; FORMÁNEK, M.; LISICKÝ, O.; BURŠA, J.

Released

11. 1. 2024

Publisher

ELSEVIER IRELAND LTD

Location

CLARE

ISBN

1872-7565

Periodical

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Year of study

245

Number

2024

State

Kingdom of the Netherlands

Pages from

108016-1

Pages to

108016-10

Pages count

10

URL