Publication detail

Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern

LEINVEBER, P. HALÁMEK, J. ČURILA, K. PRINZEN, F. LIPOLDOVÁ, J. MATEJKOVÁ, M. SMÍŠEK, R. PLEŠINGER, F. NAGY, A. NOVÁK, M. VIŠČOR, I. VONDRA, V. JURÁK, P.

Original Title

Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern

Type

journal article in Web of Science

Language

English

Original Abstract

From precordial ECG leads, the conventional determination of the negative derivative of the QRS complex (ND-ECG) assesses epicardial activation. Recently we showed that ultra-high-frequency electrocardiography (UHF-ECG) determines the activation of a larger volume of the ventricular wall. We aimed to combine these two methods to investigate the potential of volumetric and epicardial ventricular activation assessment and thereby determine the transmural activation sequence. We retrospectively analyzed 390 ECG records divided into three groups-healthy subjects with normal ECG, left bundle branch block (LBBB), and right bundle branch block (RBBB) patients. Then we created UHF-ECG and ND-ECG-derived depolarization maps and computed interventricular electrical dyssynchrony. Characteristic spatio-temporal differences were found between the volumetric UHF-ECG activation patterns and epicardial ND-ECG in the Normal, LBBB, and RBBB groups, despite the overall high correlations between both methods. Interventricular electrical dyssynchrony values assessed by the ND-ECG were consistently larger than values computed by the UHF-ECG method. Noninvasively obtained UHF-ECG and ND-ECG analyses describe different ventricular dyssynchrony and the general course of ventricular depolarization. Combining both methods based on standard 12-lead ECG electrode positions allows for a more detailed analysis of volumetric and epicardial ventricular electrical activation, including the assessment of the depolarization wave direction propagation in ventricles.

Keywords

ultra-high-frequency ECG; UHF ECG; negative derivative map; epicardial activation mapping

Authors

LEINVEBER, P.; HALÁMEK, J.; ČURILA, K.; PRINZEN, F.; LIPOLDOVÁ, J.; MATEJKOVÁ, M.; SMÍŠEK, R.; PLEŠINGER, F.; NAGY, A.; NOVÁK, M.; VIŠČOR, I.; VONDRA, V.; JURÁK, P.

Released

7. 3. 2024

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

2045-2322

Periodical

Scientific Reports

Year of study

14

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages count

11

URL

https://www.nature.com/articles/s41598-024-55789-w

Full text in the Digital Library

http://hdl.handle.net/11012/245511

BibTex

@article{BUT188371,
  author="Pavel {Leinveber} and Josef {Halámek} and Karol {Čurila} and Frits {Prinzen} and Jolana {Lipoldová} and Magdaléna {Bačo Matejková} and Radovan {Smíšek} and Filip {Plešinger} and Andrej {Nagy} and Miroslav {Novák} and Ivo {Viščor} and Vlastimil {Vondra} and Pavel {Jurák}",
  title="Ultra-high-frequency ECG volumetric and negative derivative epicardial ventricular electrical activation pattern",
  journal="Scientific Reports",
  year="2024",
  volume="14",
  number="1",
  pages="11",
  doi="10.1038/s41598-024-55789-w",
  issn="2045-2322",
  url="https://www.nature.com/articles/s41598-024-55789-w"
}