Publication detail

Monitoring the release of bioactive substances from bone scaffolds suitable for regenerative medicine applications

LYSÁKOVÁ, K. KADLECOVÁ, Z. MENČÍK, P. HLINÁKOVÁ, K. VOJTOVÁ, L.

Original Title

Monitoring the release of bioactive substances from bone scaffolds suitable for regenerative medicine applications

Type

abstract

Language

English

Original Abstract

Large bone defects pose significant challenges due to their slow healing process, often accompanied by bone inflammation. Utilizing advanced fabrication techniques offers a distinct advantage over conventional methods, primarily because it can precisely define the shape, size, and morphology of the final product. In this project, we adopted a novel approach, employing a resorbable bio-ink formulation comprising calcium phosphate (CaP) ceramic powder modified with a thixotropic biodegradable thermosensitive copolymer (originally synthesized at CEITEC BUT1). The fabricated bone scaffolds were further enhanced with bioactive proteins to expedite the healing process and suppress microbial infection. This study investigated the release kinetics of two key substances: a bioactive protein and an enzyme from the bone cement scaffolds. We focused on discerning how different methods of protein incorporation—affect the release rate of these substances. Our findings revealed distinct variations in release rates depending on the specific method of bioactive substance incorporation. Furthermore, our research extended to evaluating the susceptibility of bacterial strains to the antibacterial enzyme.

Keywords

Bone cements, protein, loading, coating

Authors

LYSÁKOVÁ, K.; KADLECOVÁ, Z.; MENČÍK, P.; HLINÁKOVÁ, K.; VOJTOVÁ, L.

Released

25. 4. 2024

Publisher

České vysoké učení technické v Praze

Location

Praha

ISBN

978-80-01-07293-6

Book

Bioimplantologie a regenerativní medicína 2024

Edition number

1

Pages from

39

Pages to

39

Pages count

56

URL

https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d

BibTex

@misc{BUT188716,
  author="Klára {Tušlová} and Zuzana {Kadlecová} and Přemysl {Menčík} and Kristýna {Hlináková} and Lucy {Vojtová}",
  title="Monitoring the release of bioactive substances from bone scaffolds suitable for regenerative medicine applications",
  booktitle="Bioimplantologie a regenerativní medicína 2024",
  year="2024",
  edition="1",
  pages="39--39",
  publisher="České vysoké učení technické v Praze",
  address="Praha",
  isbn="978-80-01-07293-6",
  url="https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d",
  note="abstract"
}