Publication detail

Self-Assembled Hydrogel Membranes with Structurally Tunable Mechanical and Biological Properties

ABDEL-RAHMAN, R. ABDELLATIF, A. FRANKOVA, J. PIANA, F. KALINA, L. GAJDOŠOVÁ, V. KAPRALKOVA, L. THOTTAPPALIJ, M.A. ANČÁŘ, J.

Original Title

Self-Assembled Hydrogel Membranes with Structurally Tunable Mechanical and Biological Properties

Type

journal article in Web of Science

Language

English

Original Abstract

Using supramolecular self-assembled nanocomposite materials made from protein and polysaccharide components is becoming more popular because of their unique properties, such as biodegradability, hierarchical structures, and tunable multifunctionality. However, the fabrication of these materials in a reproducible way remains a challenge. This study presents a new evaporation-induced self-assembly method producing layered hydrogel membranes (LHMs) using tropocollagen grafted by partially deacetylated chitin nanocrystals (CO-g-ChNCs). ChNCs help stabilize tropocollagen's helical conformation and fibrillar structure by forming a hierarchical microstructure through chemical and physical interactions. The LHMs show improved mechanical properties, cytocompatibility, and the ability to control drug release using octenidine dihydrochloride (OCT) as a drug model. Because of the high synergetic performance between CO and ChNCs, the modulus, strength, and toughness increased significantly compared to native CO. The biocompatibility of LHM was tested using the normal human dermal fibroblast (NHDF) and the human osteosarcoma cell line (Saos-2). Cytocompatibility and cell adhesion improved with the introduction of ChNCs. The extracted ChNCs are used as a reinforcing nanofiller to enhance the performance properties of tropocollagen hydrogel membranes and provide new insights into the design of novel LHMs that could be used for various medical applications, such as control of drug release in the skin and bone tissue regeneration.

Keywords

REDUCED GRAPHENE OXIDE; ARTIFICIAL NACRE; CROSS-LINKING; ANTIBACTERIAL ACTIVITY; COLLAGEN; NANOCOMPOSITES; ALGINATE; PIEZOELECTRICITY; ATTACHMENT; SCAFFOLDS

Authors

ABDEL-RAHMAN, R.; ABDELLATIF, A.; FRANKOVA, J.; PIANA, F.; KALINA, L.; GAJDOŠOVÁ, V.; KAPRALKOVA, L.; THOTTAPPALIJ, M.A.; ANČÁŘ, J.

Released

10. 6. 2024

Publisher

AMER CHEMICAL SOC

Location

WASHINGTON

ISBN

1525-7797

Periodical

BIOMACROMOLECULES

Year of study

25

Number

6

State

United States of America

Pages from

3449

Pages to

3463

Pages count

15

URL

https://pubs.acs.org/doi/10.1021/acs.biomac.4c00082

BibTex

@article{BUT188813,
  author="ABDEL-RAHMAN, R. and ABDELLATIF, A. and FRANKOVA, J. and PIANA, F. and KALINA, L. and GAJDOŠOVÁ, V. and KAPRALKOVA, L. and THOTTAPPALIJ, M.A. and ANČÁŘ, J.",
  title="Self-Assembled Hydrogel Membranes with Structurally Tunable Mechanical and Biological Properties",
  journal="BIOMACROMOLECULES",
  year="2024",
  volume="25",
  number="6",
  pages="3449--3463",
  doi="10.1021/acs.biomac.4c00082",
  issn="1525-7797",
  url="https://pubs.acs.org/doi/10.1021/acs.biomac.4c00082"
}