Publication detail

3D atlas of the human fetal chondrocranium in the middle trimester

KAISER, M. ZIKMUND, T. SIDDHARTH, V. METSCHER, B. ADAMEYKO, I. RICHMAN, J. KAISER, J.

Original Title

3D atlas of the human fetal chondrocranium in the middle trimester

Type

journal article in Web of Science

Language

English

Original Abstract

The chondrocranium provides the key initial support for the fetal brain, jaws and cranial sensory organs in all vertebrates. The patterns of shaping and growth of the chondrocranium set up species-specific development of the entire craniofacial complex. The 3D development of chondrocranium have been studied primarily in animal model organisms, such as mice or zebrafish. In comparison, very little is known about the full 3D human chondrocranium, except from drawings made by anatomists many decades ago. The knowledge of human-specific aspects of chondrocranial development are essential for understanding congenital craniofacial defects and human evolution. Here advanced microCT scanning was used that includes contrast enhancement to generate the first 3D atlas of the human fetal chondrocranium during the middle trimester (13 to 19 weeks). In addition, since cartilage and bone are both visible with the techniques used, the endochondral ossification of cranial base was mapped since this region is so critical for brain and jaw growth. The human 3D models are published as a scientific resource for human development.

Keywords

chondrocranium; human embryos; cartilage development; microCT; tomography

Authors

KAISER, M.; ZIKMUND, T.; SIDDHARTH, V.; METSCHER, B.; ADAMEYKO, I.; RICHMAN, J.; KAISER, J.

Released

13. 6. 2024

Publisher

NATURE PORTFOLIO

Location

BERLIN

ISBN

2052-4463

Periodical

Scientific data

Year of study

11

Number

1

State

United Kingdom of Great Britain and Northern Ireland

Pages from

1

Pages to

6

Pages count

6

URL

https://www.nature.com/articles/s41597-024-03455-1

Full text in the Digital Library

http://hdl.handle.net/11012/249335

BibTex

@article{BUT189053,
  author="Markéta {Kaiser} and Tomáš {Zikmund} and Vora {Siddharth} and Brian {Metscher} and Igor {Adameyko} and Joy M. {Richman} and Jozef {Kaiser}",
  title="3D atlas of the human fetal chondrocranium in the middle trimester",
  journal="Scientific data",
  year="2024",
  volume="11",
  number="1",
  pages="1--6",
  doi="10.1038/s41597-024-03455-1",
  issn="2052-4463",
  url="https://www.nature.com/articles/s41597-024-03455-1"
}