Publication detail

OLEYL-HYALURONAN SELF-ASSEMBLY AND ITS INTERACTIONS WITH BOVINE SERUM ALBUMIN

SITA, J. ČEPA, M. VELEBNÝ, V. ONDREÁŠ, F.

Original Title

OLEYL-HYALURONAN SELF-ASSEMBLY AND ITS INTERACTIONS WITH BOVINE SERUM ALBUMIN

Type

conference paper

Language

English

Original Abstract

Oleyl-hyaluronan (O-HA) is an amphiphilic polysaccharide that can be used as a drug carrier. Its self-assembly was improved when using a solvent with ions due to charge compensation on the HA backbone. Moreover, the functional properties such as drug loading capacity and its penetration into the skin were enhanced. Interactions with serum proteins are often considered a bottleneck for carriers' application. Interactions of O-HA and bovine serum albumin (BSA) were elucidated by various techniques and divided into three regimes. Structural changes were found and described. Resulting system retained the drug effectively.

Keywords

self-assembly; hyaluronan; hydrophobically modified; BSA;

Authors

SITA, J.; ČEPA, M.; VELEBNÝ, V.; ONDREÁŠ, F.

Released

1. 1. 2022

ISBN

978-80-88307-12-9

Book

PROCEEDINGS OF THE 18TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE

Pages from

110

Pages to

113

Pages count

4

URL

https://www.webofscience.com/wos/woscc/full-record/WOS:001249624200024

BibTex

@inproceedings{BUT189075,
  author="SITA, J. and ČEPA, M. and VELEBNÝ, V. and ONDREÁŠ, F.",
  title="OLEYL-HYALURONAN SELF-ASSEMBLY AND ITS INTERACTIONS WITH BOVINE SERUM ALBUMIN",
  booktitle="PROCEEDINGS OF THE 18TH INTERNATIONAL CONFERENCE ON POLYSACCHARIDES-GLYCOSCIENCE",
  year="2022",
  pages="110--113",
  isbn="978-80-88307-12-9",
  url="https://www.webofscience.com/wos/woscc/full-record/WOS:001249624200024"
}