Přístupnostní navigace
E-application
Search Search Close
Publication detail
BRÁZDA, V. ŠISLEROVÁ, L. MERGNY, J. CUCCHIARINI, A.
Original Title
G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes
Type
journal article in Web of Science
Language
English
Original Abstract
Current methods of processing archaeological samples combined with advances in sequencing methods lead to disclosure of a large part of H. neanderthalensis and Denisovans genetic information. It is hardly surprising that the genome variability between modern humans, Denisovans and H. neanderthalensis is relatively limited. Genomic studies may provide insight on the metabolism of extinct human species or lineages. Detailed analysis of G-quadruplex sequences in H. neanderthalensis and Denisovans mitochondrial DNA showed us interesting features. Relatively similar patterns in mitochondrial DNA are found compared to modern humans, with one notable exception for H. neanderthalensis. An interesting difference between H. neanderthalensis and H. sapiens corresponds to a motif found in the D-loop region of mtDNA, which is responsible for mitochondrial DNA replication. This area is directly responsible for the number of mitochondria and consequently for the efficient energy metabolism of cell. H. neanderthalensis harbor a long uninterrupted run of guanines in this region, which may cause problems for replication, in contrast with H. sapiens, for which this run is generally shorter and interrupted. One may propose that the predominant H. sapiens motif provided a selective advantage for modern humans regarding mtDNA replication and function.
Keywords
mitochondria, genome evolution, G-quadruplex, replication, paleogenomics
Authors
BRÁZDA, V.; ŠISLEROVÁ, L.; MERGNY, J.; CUCCHIARINI, A.
Released
30. 5. 2024
Publisher
OXFORD UNIV PRESS
Location
OXFORD
ISBN
2631-9268
Periodical
NAR Genomics and Bioinformatics
Year of study
6
Number
2
State
United Kingdom of Great Britain and Northern Ireland
Pages from
1
Pages to
10
Pages count
URL
https://academic.oup.com/nargab/article/6/2/lqae060/7685155?utm_source=etoc&utm_campaign=nargab&utm_medium=email
BibTex
@article{BUT189109, author="Václav {Brázda} and Lucie {Šislerová} and Jean-Louis {Mergny} and Anne {Cucchiarini}", title="G-quadruplex propensity in H. neanderthalensis, H. sapiens and Denisovans mitochondrial genomes", journal="NAR Genomics and Bioinformatics", year="2024", volume="6", number="2", pages="1--10", doi="10.1093/nargab/lqae060", issn="2631-9268", url="https://academic.oup.com/nargab/article/6/2/lqae060/7685155?utm_source=etoc&utm_campaign=nargab&utm_medium=email" }