Publication detail

Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold

SMOLNICKÁ, A. LIPOVÝ, B. PAVLIŇÁKOVÁ, V. HOLOUBEK, J. FALDYNA, M. JEKLOVÁ, E. VOJTOVÁ, L. KOUTNÁ, I.

Original Title

Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold

Type

abstract

Language

English

Original Abstract

It has been proved that cellular skin substitutes provide faster wound healing and vascularization. Suitable cells for skin substitutes are mesenchymal stromal cells (MSCs), which have anti-inflammatory properties, appropriate differentiation capacity, and promote angiogenesis. MSCs can be differentiated into fibroblasts or preadipocytes. These differentiated cells were seeded on biocompatible and biodegradable collagen-chitosan foams that serve as scaffolds. Fibroblasts cultivated in the scaffold mimic the dermis layer, and preadipocytes imitate the hypodermis. Isolated keratinocytes were seeded on top of the scaffold as an epidermis layer.

Keywords

collagen, chitosan, scaffold, dermis, regenerative medicine

Authors

SMOLNICKÁ, A.; LIPOVÝ, B.; PAVLIŇÁKOVÁ, V.; HOLOUBEK, J.; FALDYNA, M.; JEKLOVÁ, E.; VOJTOVÁ, L.; KOUTNÁ, I.

Released

25. 4. 2024

Location

Praha

ISBN

978-80-01-07293-6

Book

Bioimplantologie a regenerativní medicína 2024

Edition number

1. elektronické

Pages from

45

Pages to

45

Pages count

59

URL

https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d

BibTex

@misc{BUT189768,
  author="Anna {Smolnická} and Břetislav {Lipový} and Veronika {Pavliňáková} and Jakub {Holoubek} and Martin {Faldyna} and Edita {Jeklová} and Lucy {Vojtová} and Irena {Koutná}",
  title="Multilayered cellular skin substitute with biomimetic collagen-chitosan scaffold",
  booktitle="Bioimplantologie a regenerativní medicína 2024",
  year="2024",
  edition="1. elektronické",
  pages="45--45",
  address="Praha",
  isbn="978-80-01-07293-6",
  url="https://921c88450d.clvaw-cdnwnd.com/17e12706bb26b88046060a8921d16f31/200000499-73ed673ed8/bioimplantologie_2024_sbornik.pdf?ph=921c88450d",
  note="abstract"
}