Publication detail

Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution

DROTÁROVÁ, L. SLÁMEČKA, K. BALINT, M. REMEŠOVÁ, M. HUDÁK, R. ŽIVČÁK, J. ČELKO, L. MONTUFAR JIMENEZ, E.

Original Title

Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution

Type

journal article in Web of Science

Language

English

Original Abstract

Biodegradable magnesium implants offer a solution for bone repair without the need for implant removal. However, concerns persist regarding peri-implant gas accumulation, which has limited their widespread clinical acceptance. Consequently, there is a need to minimise the mass of magnesium to reduce the total volume of gas generated around the implants. Incorporating porosity is a direct approach to reducing the mass of the implants, but it also decreases the strength and degradation resistance. This study demonstrates that the infiltration of a calcium phosphate cement into an additively manufactured WE43 Mg alloy scaffold with 75 % porosity, followed by hydrothermal treatment, yields biodegradable magnesium/hydroxyapatite interpenetrating phase composites that generate an order of magnitude less hydrogen gas during degradation than WE43 scaffolds. The enhanced degradation resistance results from magnesium passivation, allowing osteoblast proliferation in indirect contact with composites. Additionally, the composites exhibit a compressive strength 1.8 times greater than that of the scaffolds, falling within the upper range of the compressive strength of cancellous bone. These results emphasise the potential of the new biodegradable interpenetrating phase composites for the fabrication of temporary osteosynthesis devices. Optimizing cement hardening and magnesium passivation during hydrothermal processing is crucial for achieving both high compressive strength and low degradation rate.

Keywords

Magnesium; Biodegradable metal; Calcium phosphate cement; Hydroxyapatite; Composite

Authors

DROTÁROVÁ, L.; SLÁMEČKA, K.; BALINT, M.; REMEŠOVÁ, M.; HUDÁK, R.; ŽIVČÁK, J.; ČELKO, L.; MONTUFAR JIMENEZ, E.

Released

1. 12. 2024

Publisher

KEAI PUBLISHING LTD

Location

BEIJING

ISBN

2452-199X

Periodical

Bioactive Materials

Year of study

42

Number

12

State

People's Republic of China

Pages from

519

Pages to

530

Pages count

12

URL

https://doi.org/10.1016/j.bioactmat.2024.08.048

BibTex

@article{BUT189829,
  author="DROTÁROVÁ, L. and SLÁMEČKA, K. and BALINT, M. and REMEŠOVÁ, M. and HUDÁK, R. and ŽIVČÁK, J. and ČELKO, L. and MONTUFAR JIMENEZ, E.",
  title="Biodegradable WE43 Mg alloy/hydroxyapatite interpenetrating phase composites with reduced hydrogen evolution",
  journal="Bioactive Materials",
  year="2024",
  volume="42",
  number="12",
  pages="519--530",
  doi="10.1016/j.bioactmat.2024.08.048",
  issn="2452-199X",
  url="https://doi.org/10.1016/j.bioactmat.2024.08.048"
}