Publication detail

Method Comparison for Bone Density in Multiple Myeloma Patients

NOHEL, M. MÉZL, M. VÁLEK, V. DOSTÁL, M. CHMELÍK, J.

Original Title

Method Comparison for Bone Density in Multiple Myeloma Patients

Type

journal article in Scopus

Language

English

Original Abstract

Bone mineral density (BMD) is an important indicator of bone health, particularly in patients with conditions such as multiple myeloma. This study aims to compare three methodologies for quantifying BMD in vertebral regions affected by lytic lesions: two using data from conventional CT with different corrections for tissue composition, and one using data acquired on a dual-energy CT system. Method 1 is based on conventional CT with corrections using reference values for muscle and fat, Method 2 uses conventional CT with corrections based on the measured CT values of paraspinal muscle, and Method 3 is based on dual-energy CT. The Wilcoxon signed-rank test was used for statistical comparison, as the dataset did not follow a normal distribution. The results indicated significant differences between Methods 1 and 2 for BMD in regions of interest (ROIs) within lytic lesions, while no significant differences were found for other comparisons in this group. For vertebrae affected by multiple myeloma, significant differences were found between Methods 1 and 2, and Methods 2 and 3, but not between Methods 1 and 3. In healthy vertebrae, a significant difference was found only between Methods 2 and 3. When all ROIs were combined, significant differences were found between Methods 1 and 2, and Methods 2 and 3, with no difference between Methods 1 and 3. Future research will focus on objectively assessing the accuracy of these methods by comparing their results with a calibration phantom.

Keywords

Spine, bone mineral density, BMD, Multiple myeloma, spectral CT

Authors

NOHEL, M.; MÉZL, M.; VÁLEK, V.; DOSTÁL, M.; CHMELÍK, J.

Released

30. 9. 2024

Publisher

Czech Society for Biomedical Engineering and Medical Informatics

Location

Praha

ISBN

0301-5491

Periodical

Lékař a technika

Year of study

54

Number

3

State

Czech Republic

Pages from

94

Pages to

100

Pages count

7

URL

https://doi.org/10.14311/CTJ.2024.3.04

BibTex

@article{BUT190125,
  author="Michal {Nohel} and Martin {Mézl} and Vlastimil {Válek} and Marek {Dostál} and Jiří {Chmelík}",
  title="Method Comparison for Bone Density in Multiple Myeloma Patients",
  journal="Lékař a technika",
  year="2024",
  volume="54",
  number="3",
  pages="94--100",
  doi="10.14311/CTJ.2024.3.04",
  issn="0301-5491",
  url="https://doi.org/10.14311/CTJ.2024.3.04"
}