Publication detail

Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair

OLIVER URRUTIA, C. KASHIMBETOVA, A. SLÁMEČKA, K. CASAS LUNA, M. MATULA, J. KOLEDOVÁ, Z. KAISER, J. ČELKO, L. MONTUFAR JIMENEZ, E.

Original Title

Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair

Type

journal article in Web of Science

Language

English

Original Abstract

This study introduces the first fabrication of porous titanium/hydroxyapatite interpenetrating phase composites through an innovative processing method. The approach combines additive manufacturing of a customized titanium skeleton with the infiltration of an injectable hydroxyapatite foam, followed by in situ foam hardening at physiological temperature. This biomimetic process circumvents ceramic sintering and metal casting, effectively avoiding the formation of secondary phases that can impair mechanical performance. Hydroxyapatite foams, prepared using two foaming agents (polysorbate 80 and gelatine), significantly reinforce the titanium skeleton while preserving the microstructural characteristics essential for osteoinductive properties. The strengthening mechanisms rely on the conformation of the foams to the titanium surface, thereby enabling stable mechanical interlocking and effective interfacial stress transfer. This, combined with the mechanical constriction of phases, enhances damage tolerance and mechanical reliability of the interpenetrating phase composites. In addition, the interpenetrating phase composites feature a network of concave pores with an optimal size for bone repair, support human osteoblast proliferation, and exhibit mechanical properties compatible with bone, offering a promising solution for the efficient and personalized reconstruction of large bone defects. The results demonstrate a significant advancement in composite fabrication, integrating the benefits of additive manufacturing for bone repair with the osteogenic capacity of calcium phosphate ceramics.

Keywords

Titanium; Hydroxyapatite; Infiltration; Self-hardening; Ceramic matrix composite; Bone repair

Authors

OLIVER URRUTIA, C.; KASHIMBETOVA, A.; SLÁMEČKA, K.; CASAS LUNA, M.; MATULA, J.; KOLEDOVÁ, Z.; KAISER, J.; ČELKO, L.; MONTUFAR JIMENEZ, E.

Released

1. 1. 2025

Publisher

ELSEVIER

Location

AMSTERDAM

ISBN

2772-9508

Periodical

BIOMATERIALS ADVANCES

Year of study

166

Number

214079

State

Kingdom of the Netherlands

Pages count

11

URL

https://www.webofscience.com/wos/woscc/full-record/WOS:001348405100001

BibTex

@article{BUT193664,
  author="Carolina {Oliver Urrutia} and Adelia {Kashimbetova} and Karel {Slámečka} and Mariano {Casas Luna} and Jan {Matula} and Zuzana {Koledová} and Jozef {Kaiser} and Ladislav {Čelko} and Edgar Benjamin {Montufar Jimenez}",
  title="Porous titanium/hydroxyapatite interpenetrating phase composites with optimal mechanical and biological properties for personalized bone repair",
  journal="BIOMATERIALS ADVANCES",
  year="2025",
  volume="166",
  number="214079",
  pages="11",
  doi="10.1016/j.bioadv.2024.214079",
  issn="2772-9508",
  url="https://www.webofscience.com/wos/woscc/full-record/WOS:001348405100001"
}