Publication result detail

A New Approach to Define Dynamics of the Ion Channel Gates

OZER, M., ERDEM, R., PROVAZNÍK, I.

Original Title

A New Approach to Define Dynamics of the Ion Channel Gates

English Title

A New Approach to Define Dynamics of the Ion Channel Gates

Type

Peer-reviewed article not indexed in WoS or Scopus

Original Abstract

Voltage-gated ion channels are of great importance in the generation and propagation of electrical signals in the excitable cellmembranes. How these channels respond to changes in the potential across themembrane has been a challenging problem, and different approaches have been proposed to address the mechanism of voltage sensing and gating in these channels. In this study, we attempt a new approach by considering a simple two-state gate system and applying the path probability method to construct a nonequilibrium statistical mechanical model of the system. The model which is based on the principles of statistical physics provides a firm physical basis for ion channel gating.

English abstract

Voltage-gated ion channels are of great importance in the generation and propagation of electrical signals in the excitable cellmembranes. How these channels respond to changes in the potential across themembrane has been a challenging problem, and different approaches have been proposed to address the mechanism of voltage sensing and gating in these channels. In this study, we attempt a new approach by considering a simple two-state gate system and applying the path probability method to construct a nonequilibrium statistical mechanical model of the system. The model which is based on the principles of statistical physics provides a firm physical basis for ion channel gating.

Keywords

(In)Activation gate; Ion channel; Path probability method; Statistical mechanics

Key words in English

(In)Activation gate; Ion channel; Path probability method; Statistical mechanics

Authors

OZER, M., ERDEM, R., PROVAZNÍK, I.

RIV year

2011

Released

01.02.2004

Publisher

Lippincott Williams & Wilkins

ISBN

0959-4965

Periodical

NEUROREPORT

Volume

15

Number

2

State

United States of America

Pages from

335

Pages count

4

BibTex

@article{BUT41553,
  author="Mahmut {Ozer} and Riza {Erdem} and Valentýna {Provazník}",
  title="A New Approach to Define Dynamics of the Ion Channel Gates",
  journal="NEUROREPORT",
  year="2004",
  volume="15",
  number="2",
  pages="4",
  issn="0959-4965"
}