Synthesis and characterization of biocompatible hydrogels

journal article - other

English

The proposed project is focused on the synthesis, characterization and degradation kinetic study of well-defined multifunctional biocompatible and biodegradable polymer materials with controlled life-time additionally modified by renewable raw materials. These amphiphilic copolymers are based on the biodegradable macromonomers of hydrophilic poly(ethylene glycol) (PEG) with hydrophobic copolymer of lactic and glycolic acid (PLA/PGA), which are functionalized by itaconic acid. By changing the molecular weight and molar ratio of these compounds, amphiphilic character of resulted PEG-co-PLA/PGA macromonomers as well as the functional groups separation and, moreover, the kinetic of degradation is affected. Well-defined multifunctional macromonomers can be chemically or physically cross-linked in order to make 3D-polymer network Suggested materials might be further modified by an active chemical compounds to become candidates for a broad range of applications such as biomedical (e.g. injectable polymer drug delivery systems, tissue implants, resorbable adhesives), agricultural (controlled fertilizer and seed release films), industrial (breathable disposable protective cloth fabric) and environmental (waste-free production).

biocompatible, renewable raw materials, sol-gel transition

VOJTOVÁ, L.; JANČÁŘ, J.

2005

25. 8. 2005

Česká společnost chemická

Praha

0009-2770

Chemické listy

99 (S)

Symposia

Czech Republic

s491

s492

2

http://chemicke-listy.vscht.cz