Publication detail

Anthracycline Therapy and 24-Hour Blood-Pressure Profile in Long-Term Survivors of Childhood Cancer

NOVÁKOVÁ, Z. ŠŤASTNÁ, J. HONZÍKOVÁ, K. HRSTKOVÁ, H. HONZÍKOVÁ, N. ZÁVODNÁ, E. FIŠER, B. HONZÍK, P.

Original Title

Anthracycline Therapy and 24-Hour Blood-Pressure Profile in Long-Term Survivors of Childhood Cancer

Type

journal article in Web of Science

Language

English

Original Abstract

In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure. Sixty four aged-matched subjects served as controls. The differences between mean values of systolic (SBP) and diastolic blood pressure (DBP) in each hour of both groups were evaluated by Mann-Whitney test. Also the parameters of the least-squares fit of the sinusoidal curve in each subject were estimated (M - mesor, midline-estimating, a mean value of sinusoidal curve corresponds to 24-hours mean pressure; A amplitude, double amplitude corresponds to night-day difference; Acr - acrophase is a time of maximal value of a sinusoidal curve). SBP and DBP was significantly lower only during night hours in anthracycline patients 19-22 years old. Also M was lower in this age subgroup of patients comparing to age matched controls (SBP: 112 +/- 6 mm Hg versus 117 +/- 7 mm Hg, p<0.05; DBP: 67 +/- 3 mm Hg versus 69 +/- 6 mm Hg, p<0.05), A was not different, Acr in patients was shifted one hour earlier (SBP: 2.4 p.m. versus 3.6 p.m., p<0.05; DBP: 2.1 p.m. versus 3.3 p.m., p<0.01). This corresponds to the shift of the morning blood-pressure increase seen on 24-hours blood pressure profiles. M correlated with age in controls (SBP: r=0.374, p<0.01; regression coefficient b=1.34 mm Hg/1 year; DBP: r=0.365, p<0.01; b=0.95 mm Hg/1 year), but not in patients (SBP: r=0.182, DBP: r=0.064). A and Acr were age-independent in all subjects. It is concluded that blood pressure in 19-22 years old AC patients is lower during night hours, the age-dependent increase of blood pressure seen in healthy controls between 13 and 22 years of age does not occur in patients. This finding is consistent with the long-lasting impairment of the sympathetic nervous system caused by anthracyclines.

Keywords

Anthracyclines; Blood pressure; Cardiotoxicity; Childhood cancer; Chronobiology

Authors

NOVÁKOVÁ, Z.; ŠŤASTNÁ, J.; HONZÍKOVÁ, K.; HRSTKOVÁ, H.; HONZÍKOVÁ, N.; ZÁVODNÁ, E.; FIŠER, B.; HONZÍK, P.

RIV year

2010

Released

1. 6. 2010

Publisher

Institute of Physiology

Location

Academy of Science of the Czech Republic, Prague

ISBN

0862-8408

Periodical

Physiological Research

Year of study

59

Number

1

State

Czech Republic

Pages from

97

Pages to

102

Pages count

6

URL

http://www.biomed.cas.cz/physiolres/pdf/59%20Suppl%201/59_S97.pdf

BibTex

@article{BUT49926,
  author="Zuzana {Nováková} and Jana {Šťastná} and Klára {Honzíková} and Hana {Hrstková} and Nataša {Honzíková} and Eva {Závodná} and Bohumil {Fišer} and Petr {Honzík}",
  title="Anthracycline Therapy and 24-Hour Blood-Pressure Profile in Long-Term Survivors of Childhood Cancer",
  journal="Physiological  Research",
  year="2010",
  volume="59",
  number="1",
  pages="97--102",
  issn="0862-8408",
  url="http://www.biomed.cas.cz/physiolres/pdf/59%20Suppl%201/59_S97.pdf"
}