Publication detail

Optimisation of solid phase extraction of selected non-steroidal anti-inflammatory drugs by capillary zone electrophoresis

ČAPKA, L. LACINA, P. VÁVROVÁ, M.

Original Title

Optimisation of solid phase extraction of selected non-steroidal anti-inflammatory drugs by capillary zone electrophoresis

Type

abstract

Language

English

Original Abstract

Presented study is focused on SPE development for extraction selected acidic drug residues from water environment. Target drugs are chosen from the group of non-steroidal anti-inflammatory drugs: salicylic acid, diclofenac, ibuprofen, ketoprofen, naproxen and acetaminophen. Increasing presence and concentrations of pharmaceuticals in the environment have been ob-served for some last decades. The most heavily loaded environment is aquatic environment due to continuous discharge of these compounds into sewer system and their insufficient eli-mination during cleaning processes in wastewater treatment plants. Pharmaceuticals are pollu-tants, which not exhibit acute toxicity for water organisms, but their continuous release into the environment may cause chronic adverse effects on these organisms. Due to this potential threat is necessary to control their presence in aquatic environment. Therefore, there is a need to apply reliable analytical methods for easy determination of these compounds. One of the most common extraction method for extraction of many compounds from water is solid phase extraction. Optimisation of the SPE method contains effeciency of extraction, despending of pH and volume of loaded sample and volume of elution solvent. In addition, this study presents using of capillary zone electrophoresis as a very suitable analytical method for final analysis of these residues. Work in this study includes experimental development of these methods for their possible use not only for determination of selected drug residues, but also for determination of another similar compounds from real samples of water.

Keywords

non-steroidal drugs, capillary zone electrophoresis, solid phase extraction, waste water

Authors

ČAPKA, L.; LACINA, P.; VÁVROVÁ, M.

Released

25. 9. 2011

Location

Ioannina

BibTex

@misc{BUT73800,
  author="Lukáš {Alexa} and Petr {Lacina} and Milada {Vávrová}",
  title="Optimisation of solid phase extraction of selected non-steroidal anti-inflammatory drugs by capillary zone electrophoresis",
  booktitle="16th International Symposium on Environmental Pollution and its Impact on Life in the Mediterranean Region: Book of Abstracts",
  year="2011",
  address="Ioannina",
  note="abstract"
}