Publication detail

Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma

GUMULEC, J. MASAŘÍK, M. KŘÍŽKOVÁ, S. ADAM, V. HUBÁLEK, J. HRABĚTA, J. ECKSCHLAGER, T. STIBOROVÁ, M. KIZEK, R.

Original Title

Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma

Type

journal article in Web of Science

Language

English

Original Abstract

MT protects cells against oxidative stress, because it cooperates with reduced glutathione (GSH). Recent studies indicate elevated serum level of MT in a number of malignancies, among others in breast, and prostate. MT together with zinc(II) affect apoptosis and proliferation, thus together with its antioxidative effects it may affect cancer. To date, only little is known about the influence of zinc(II) and MT on cancer, while these compounds may play an important role in pathogenesis. This review concludes current data regarding the impact of zinc(II) on the pathogenesis of breast and prostate cancers with potential outlines of new, targeted therapy and prevention. Moreover, blood plasma zinc(II) and MT levels and dietary zinc(II) intake are discussed in relation to breast and prostate cancer risk.

Keywords

Zinc, Cancer, Prostate Carcinoma, Breast Carcinoma, Homeostasis, Low Molecular Mass Thiols, Metallothionein, Glutathione, Zinc Intake, Apoptosis, ZnT and ZIP transporters

Authors

GUMULEC, J.; MASAŘÍK, M.; KŘÍŽKOVÁ, S.; ADAM, V.; HUBÁLEK, J.; HRABĚTA, J.; ECKSCHLAGER, T.; STIBOROVÁ, M.; KIZEK, R.

RIV year

2011

Released

1. 11. 2011

ISBN

0929-8673

Periodical

CURRENT MEDICINAL CHEMISTRY

Year of study

2011 (18)

Number

33

State

United Arab Emirates

Pages from

5041

Pages to

5051

Pages count

11

BibTex

@article{BUT75099,
  author="GUMULEC, J. and MASAŘÍK, M. and KŘÍŽKOVÁ, S. and ADAM, V. and HUBÁLEK, J. and HRABĚTA, J. and ECKSCHLAGER, T. and STIBOROVÁ, M. and KIZEK, R.",
  title="Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma",
  journal="CURRENT MEDICINAL CHEMISTRY",
  year="2011",
  volume="2011 (18)",
  number="33",
  pages="5041--5051",
  issn="0929-8673"
}