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GUMULEC, J. MASAŘÍK, M. KŘÍŽKOVÁ, S. ADAM, V. HUBÁLEK, J. HRABĚTA, J. ECKSCHLAGER, T. STIBOROVÁ, M. KIZEK, R.
Original Title
Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma
Type
journal article in Web of Science
Language
English
Original Abstract
MT protects cells against oxidative stress, because it cooperates with reduced glutathione (GSH). Recent studies indicate elevated serum level of MT in a number of malignancies, among others in breast, and prostate. MT together with zinc(II) affect apoptosis and proliferation, thus together with its antioxidative effects it may affect cancer. To date, only little is known about the influence of zinc(II) and MT on cancer, while these compounds may play an important role in pathogenesis. This review concludes current data regarding the impact of zinc(II) on the pathogenesis of breast and prostate cancers with potential outlines of new, targeted therapy and prevention. Moreover, blood plasma zinc(II) and MT levels and dietary zinc(II) intake are discussed in relation to breast and prostate cancer risk.
Keywords
Zinc, Cancer, Prostate Carcinoma, Breast Carcinoma, Homeostasis, Low Molecular Mass Thiols, Metallothionein, Glutathione, Zinc Intake, Apoptosis, ZnT and ZIP transporters
Authors
GUMULEC, J.; MASAŘÍK, M.; KŘÍŽKOVÁ, S.; ADAM, V.; HUBÁLEK, J.; HRABĚTA, J.; ECKSCHLAGER, T.; STIBOROVÁ, M.; KIZEK, R.
RIV year
2011
Released
1. 11. 2011
ISBN
0929-8673
Periodical
CURRENT MEDICINAL CHEMISTRY
Year of study
2011 (18)
Number
33
State
United Arab Emirates
Pages from
5041
Pages to
5051
Pages count
11
BibTex
@article{BUT75099, author="GUMULEC, J. and MASAŘÍK, M. and KŘÍŽKOVÁ, S. and ADAM, V. and HUBÁLEK, J. and HRABĚTA, J. and ECKSCHLAGER, T. and STIBOROVÁ, M. and KIZEK, R.", title="Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma", journal="CURRENT MEDICINAL CHEMISTRY", year="2011", volume="2011 (18)", number="33", pages="5041--5051", issn="0929-8673" }