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KREJČOVÁ, L. FABRIK, I. HYNEK, D. KŘÍŽKOVÁ, S. GUMULEC, J. VACULOVIČOVÁ, M. ADAM, V. BABULA, P. TRNKOVÁ, L. STIBOROVÁ, M. HUBÁLEK, J. MASAŘÍK, M. BINKOVÁ, H. ECKSCHLAGER, T. KIZEK, R.
Original Title
Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours
Type
journal article in Web of Science
Language
English
Original Abstract
There are more than half of million patients who fall ill with head and neck carcinoma per year, which 6 % of annually newly diagnosed malignant diseases in the world. The most important objective of this study is the electrochemical monitoring of metallothionein levels in patients with primary malignant tumors in head and neck examination and the suitability of electrochemical detection as a technique used in clinical practice. In conclusion, MT levels are closely associated with the rate of tumour differentiation, stage of tumour disease and tumour cell characteristics. Our study demonstrates not only changes in blood MT levels in patients suffering from malignant tumour disease in head and neck area, but also suitability of electrochemical techniques for blood analysis.
Keywords
electrochemical detection; head and neck cancer; voltammetry; catalytic signal; metallothionein; marker
Authors
KREJČOVÁ, L.; FABRIK, I.; HYNEK, D.; KŘÍŽKOVÁ, S.; GUMULEC, J.; VACULOVIČOVÁ, M.; ADAM, V.; BABULA, P.; TRNKOVÁ, L.; STIBOROVÁ, M.; HUBÁLEK, J.; MASAŘÍK, M.; BINKOVÁ, H.; ECKSCHLAGER, T.; KIZEK, R.
RIV year
2012
Released
1. 3. 2012
ISBN
1452-3981
Periodical
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
Year of study
7
Number
3
State
Republic of Serbia
Pages from
1767
Pages to
1784
Pages count
18
BibTex
@article{BUT90342, author="Ludmila {Krejčová} and Ivo {Fabrik} and David {Hynek} and Soňa {Křížková} and Jaromír {Gumulec} and Markéta {Vaculovičová} and Vojtěch {Adam} and Petr {Babula} and Libuše {Trnková} and Marie {Stiborová} and Jaromír {Hubálek} and Michal {Masařík} and Hana {Binková} and Tomáš {Eckschlager} and René {Kizek}", title="Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours", journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE", year="2012", volume="7", number="3", pages="1767--1784", issn="1452-3981" }