Publication detail

Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours

KREJČOVÁ, L. FABRIK, I. HYNEK, D. KŘÍŽKOVÁ, S. GUMULEC, J. VACULOVIČOVÁ, M. ADAM, V. BABULA, P. TRNKOVÁ, L. STIBOROVÁ, M. HUBÁLEK, J. MASAŘÍK, M. BINKOVÁ, H. ECKSCHLAGER, T. KIZEK, R.

Original Title

Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours

Type

journal article in Web of Science

Language

English

Original Abstract

There are more than half of million patients who fall ill with head and neck carcinoma per year, which 6 % of annually newly diagnosed malignant diseases in the world. The most important objective of this study is the electrochemical monitoring of metallothionein levels in patients with primary malignant tumors in head and neck examination and the suitability of electrochemical detection as a technique used in clinical practice. In conclusion, MT levels are closely associated with the rate of tumour differentiation, stage of tumour disease and tumour cell characteristics. Our study demonstrates not only changes in blood MT levels in patients suffering from malignant tumour disease in head and neck area, but also suitability of electrochemical techniques for blood analysis.

Keywords

electrochemical detection; head and neck cancer; voltammetry; catalytic signal; metallothionein; marker

Authors

KREJČOVÁ, L.; FABRIK, I.; HYNEK, D.; KŘÍŽKOVÁ, S.; GUMULEC, J.; VACULOVIČOVÁ, M.; ADAM, V.; BABULA, P.; TRNKOVÁ, L.; STIBOROVÁ, M.; HUBÁLEK, J.; MASAŘÍK, M.; BINKOVÁ, H.; ECKSCHLAGER, T.; KIZEK, R.

RIV year

2012

Released

1. 3. 2012

ISBN

1452-3981

Periodical

INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE

Year of study

7

Number

3

State

Republic of Serbia

Pages from

1767

Pages to

1784

Pages count

18

BibTex

@article{BUT90342,
  author="Ludmila {Krejčová} and Ivo {Fabrik} and David {Hynek} and Soňa {Křížková} and Jaromír {Gumulec} and Markéta {Vaculovičová} and Vojtěch {Adam} and Petr {Babula} and Libuše {Trnková} and Marie {Stiborová} and Jaromír {Hubálek} and Michal {Masařík} and Hana {Binková} and Tomáš {Eckschlager} and René {Kizek}",
  title="Metallothionein Electrochemically Determined using Brdicka Reaction as a Promising Blood Marker of Head and Neck Malignant Tumours",
  journal="INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE",
  year="2012",
  volume="7",
  number="3",
  pages="1767--1784",
  issn="1452-3981"
}