Publication detail

Electrochemical analysis of DNA and cadmium ions interaction

HÚSKA, D. SLAVÍK, J. ADAM, V. TRNKOVÁ, L. KIZEK, R.

Original Title

Electrochemical analysis of DNA and cadmium ions interaction

Type

conference paper

Language

English

Original Abstract

Cadmium (Cd) is a highly toxic environmental pollutant dangerous especially due to the ability of accumulation. Cd is emitted to the environment mostly by metallurgy, mining industry and production of nickel-cadmium batteries. The intoxication is caused mostly by cigarette smoke, foodstuffs and air pollution. The connection between cadmium and prostate, lung and testicles cancer as well as kidney and liver failure, lung oedema and spondylomalacia was proven. (Tokumoto 2011). Cd also generates reactive oxygen forms, damage DNA influence the function of proteins connected with an antioxidant defence of the organism. This work is focused on monitoring of the interactions between Cd ions and chicken genome DNA by square wave voltammetry on hanging mercury drop electrode. Significant signal decrease of 25% and 80% was observed in DNA exposed to Cd ions for 1 hour and 3 days, respectively.

Keywords

Electrochemical analysis, DNA, Cadmium

Authors

HÚSKA, D.; SLAVÍK, J.; ADAM, V.; TRNKOVÁ, L.; KIZEK, R.

RIV year

2011

Released

1. 6. 2011

Publisher

Mendelova univerzita v Brně

Location

Brno

ISBN

978-80-7375-514-0

Book

XI. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků

Pages from

144

Pages to

147

Pages count

4

BibTex

@inproceedings{BUT93099,
  author="Dalibor {Húska} and Jan {Slavík} and Vojtěch {Adam} and Libuše {Trnková} and René {Kizek}",
  title="Electrochemical analysis of DNA and cadmium ions interaction",
  booktitle="XI. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků",
  year="2011",
  pages="144--147",
  publisher="Mendelova univerzita v Brně",
  address="Brno",
  isbn="978-80-7375-514-0"
}