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HÚSKA, D. SLAVÍK, J. ADAM, V. TRNKOVÁ, L. KIZEK, R.
Original Title
Electrochemical analysis of DNA and cadmium ions interaction
Type
conference paper
Language
English
Original Abstract
Cadmium (Cd) is a highly toxic environmental pollutant dangerous especially due to the ability of accumulation. Cd is emitted to the environment mostly by metallurgy, mining industry and production of nickel-cadmium batteries. The intoxication is caused mostly by cigarette smoke, foodstuffs and air pollution. The connection between cadmium and prostate, lung and testicles cancer as well as kidney and liver failure, lung oedema and spondylomalacia was proven. (Tokumoto 2011). Cd also generates reactive oxygen forms, damage DNA influence the function of proteins connected with an antioxidant defence of the organism. This work is focused on monitoring of the interactions between Cd ions and chicken genome DNA by square wave voltammetry on hanging mercury drop electrode. Significant signal decrease of 25% and 80% was observed in DNA exposed to Cd ions for 1 hour and 3 days, respectively.
Keywords
Electrochemical analysis, DNA, Cadmium
Authors
HÚSKA, D.; SLAVÍK, J.; ADAM, V.; TRNKOVÁ, L.; KIZEK, R.
RIV year
2011
Released
1. 6. 2011
Publisher
Mendelova univerzita v Brně
Location
Brno
ISBN
978-80-7375-514-0
Book
XI. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků
Pages from
144
Pages to
147
Pages count
4
BibTex
@inproceedings{BUT93099, author="Dalibor {Húska} and Jan {Slavík} and Vojtěch {Adam} and Libuše {Trnková} and René {Kizek}", title="Electrochemical analysis of DNA and cadmium ions interaction", booktitle="XI. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků", year="2011", pages="144--147", publisher="Mendelova univerzita v Brně", address="Brno", isbn="978-80-7375-514-0" }