Přístupnostní navigace
E-application
Search Search Close
Publication detail
KŘÍŽKOVÁ,S. MASAŘÍK,M. KUKAČKA,J. PRŮŠA,R. ECKSCHLAGER,T., HUBALEK,J. KIZEK,R.
Original Title
Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines
Type
abstract
Language
English
Original Abstract
Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to the formation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines.
Keywords
Metallothioneins (MTs), cytostatics, prostatic cancer
Authors
KŘÍŽKOVÁ,S.; MASAŘÍK,M.; KUKAČKA,J.; PRŮŠA,R.; ECKSCHLAGER,T., HUBALEK,J.; KIZEK,R.
Released
26. 7. 2010
Publisher
EJC SUPPLEMENTS
Location
Oslo, NORWAY
ISBN
1359-6349
Periodical
Year of study
8
Number
5
State
United Kingdom of Great Britain and Northern Ireland
Pages from
49
Pages to
Pages count
1
BibTex
@misc{BUT93598, author="KŘÍŽKOVÁ,S. and MASAŘÍK,M. and KUKAČKA,J. and PRŮŠA,R. and ECKSCHLAGER,T., HUBALEK,J. and KIZEK,R.", title="Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines", year="2010", journal="EJC SUPPLEMENTS", volume="8", number="5", pages="49--49", publisher="EJC SUPPLEMENTS", address="Oslo, NORWAY", issn="1359-6349", note="abstract" }