Publication detail

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

KŘÍŽKOVÁ,S. MASAŘÍK,M. KUKAČKA,J. PRŮŠA,R. ECKSCHLAGER,T., HUBALEK,J. KIZEK,R.

Original Title

Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines

Type

abstract

Language

English

Original Abstract

Metallothioneins (MTs) are heavy-metal binding cysteine-rich proteins. MTs are thought to play a role in tumour disease. They can be used for studying of course, prognosis and metastating of a tumour. The enhanced MTs expression leads to the formation of cytostatics resistance in tumour cells. One the current accepted opinion is that these mechanisms are closely connected to ability of MT to bind heavy metal ions and form aggregates. The aim of this work was to study the changes in aggregation of MT under various concentrations of zinc and different redox conditions in human prostatic cell lines.

Keywords

Metallothioneins (MTs), cytostatics, prostatic cancer

Authors

KŘÍŽKOVÁ,S.; MASAŘÍK,M.; KUKAČKA,J.; PRŮŠA,R.; ECKSCHLAGER,T., HUBALEK,J.; KIZEK,R.

Released

26. 7. 2010

Publisher

EJC SUPPLEMENTS

Location

Oslo, NORWAY

ISBN

1359-6349

Periodical

EJC SUPPLEMENTS

Year of study

8

Number

5

State

United Kingdom of Great Britain and Northern Ireland

Pages from

49

Pages to

49

Pages count

1

BibTex

@misc{BUT93598,
  author="KŘÍŽKOVÁ,S. and MASAŘÍK,M. and KUKAČKA,J. and PRŮŠA,R. and ECKSCHLAGER,T., HUBALEK,J. and KIZEK,R.",
  title="Study of zinc-dependent aggregation of metallothionein from human prostatic cancer cell lines",
  year="2010",
  journal="EJC SUPPLEMENTS",
  volume="8",
  number="5",
  pages="49--49",
  publisher="EJC SUPPLEMENTS",
  address="Oslo, NORWAY",
  issn="1359-6349",
  note="abstract"
}